Chinese Journal of Applied Chemistry ›› 2016, Vol. 33 ›› Issue (5): 549-553.DOI: 10.11944/j.issn.1000-0518.2016.05.150412

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Synthesis and Properties of Novel Nicotinamide Adenine Dinucluotide (NAD+) Analogs

HOU Shuhua(),QU Zhongguo,ZHONG Keli,BIAN Yanjiang,TANG Lijun   

  1. Department of Chemistry,Bohai University,Jinzhou,Liaoning 121013,China
  • Accepted:2016-03-09 Published:2016-04-29 Online:2016-04-29
  • Contact: HOU Shuhua

Abstract:

Three novel stable nicotinamide adenine dinucleotide(NAD+) analogs were synthesized and characterized by 1H NMR, 13C NMR, 31P NMR and HRMS. The NAD+ analogs show good stability after heating at 80 ℃ for 24 h. Cyclic voltammetry(CV) measurement of the electrochemical properties of NAD+ analogs shows that they remain good redox activities.

Key words: nicotinamide adenine dinucleotide, analogs, redox activity