Synthesis and Biological Activity of the Novel Mannich Bases of 5-Alkyl-1,2,4-triazole

doi:10.11944/j.issn.1000-0518.2016.05.150267

Chinese Journal of Applied Chemistry ›› 2016, Vol. 33 ›› Issue (5): 554-564.DOI: 10.11944/j.issn.1000-0518.2016.05.150267

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Synthesis and Biological Activity of the Novel Mannich Bases of 5-Alkyl-1,2,4-triazole

ZHANG Chenglu(),CHENG Anqi,TANG Jie,GUO Yang,XI Huan

College of Chemistry and Chemical Engineering,Liaoning Normal University,Dalian,Liaoning 116029,China

Received:2015-07-28 Accepted:2015-12-07 Published:2016-04-29 Online:2016-04-29
Contact: ZHANG Chenglu
Supported by:
Supported by Technology Research Program of Liaoning Provincial Department of Education(No.2009A426)

Abstract

Abstract:

Twenty-two novel Mannich bases of 5-alkyl-1,2,4-triazole were designed and synthesized to evaluate their biological activities. The plant growth regulating activity, herbicidal activity and the inhibitory activity on cell division cycle protein 25B(CDC25B) of those molecules were screened. Most of the molecules exhibit good cytokinin activity and herbicidal activity, indicating their potential as novel pesticide. One of these molecules performs good inhibitory activity against CDC25B, and is a potential leading compound for anti-concer drug design.

Key words: alkyl-triazole, Mannich base, plant growth regulator, herbicidal activity, inhibitors against CDC25B

ZHANG Chenglu, CHENG Anqi, TANG Jie, GUO Yang, XI Huan. Synthesis and Biological Activity of the Novel Mannich Bases of 5-Alkyl-1,2,4-triazole[J]. Chinese Journal of Applied Chemistry, 2016, 33(5): 554-564.

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Synthesis and Biological Activity of the Novel Mannich Bases of 5-Alkyl-1,2,4-triazole

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