多肽类自组装纳米材料对抗细菌耐药的研究进展

doi:10.19894/j.issn.1000-0518.210057

摘要/Abstract

摘要： 细菌感染,尤其是耐药性细菌感染,是人类健康的巨大威胁之一。多肽类药物具有生物相容性较好、不易引起细菌产生耐药等特点,在耐药细菌感染的治疗中起着重要的作用。其中,由多肽自组装纳米材料制备的仿生纳米结构在抗耐药菌感染方面展现出独特的优势。多肽自组装纳米材料能够规避与细菌耐药性相关的机制,其作用靶点通常是在细菌不易引起耐药的细胞膜上,目前已被用于耐药性细菌感染的治疗中。除此之外,多肽自组装纳米材料独特的粒径和生物学特性使它们能够作用于细菌生物被膜,治疗顽固性细菌感染。因此,利用不同组分的作用特点构建多肽自组装纳米材料来应对耐药菌感染具有重要意义。本文总结了多肽的二级结构和由多肽自组装形成的纳米结构;详细介绍了多肽自组装纳米材料抗耐药菌的策略;最后,阐述了多肽自组装纳米材料作为抗菌剂在临床应用的前景和仍存在的挑战,希望为它们的进一步应用提供参考。

关键词: 多肽, 自组装, 纳米材料, 抗耐药菌

Abstract: Bacterial infections, especially drug-resistant bacterial infections, are one of the greatest threats to human health. Peptides play an important role in the treatment of drug-resistant bacterial infections due to their good biocompatibility and a mechanism significantly less prone to inducing resistance. Among them, the biomimetic nanostructures prepared from peptide self-assembled nanomaterials show unique advantages in resisting infections by resistant-bacteria. Nowadays, peptide self-assembled nanomaterials have been used in the treatment of drug-resistant bacterial infections. For example, they often target at cell membranes where bacterias are less likely to develop resistance. In addition, peptide self-assembled nanomaterials have a good advantage of acting on bacterial biofilms and treating intractable bacterial infections because of their unique particle size and biological characteristics. Therefore, it is of great significance to fight against drug-resistant bacterial infections with peptide self-assembled nanomaterials consisted of different components. In this review, the secondary structure of peptides and the main nanostructures formed by peptide self-assembly were summarized. What′s more, the strategies of peptide self-assembled nanomaterials against drug-resistant bacteria were demonstrated. Finally, the prospects and remaining challenges of peptide self-assembled nanomaterials as antibacterial agents in clinical applications were introduced. Therefore, we hope to provide some references for their further applications by this minireview.

Key words: Peptide, Self-assembly, Nanomaterials, Resistance to drug-resistant bacteria

中图分类号:

O631

刘娇, 邹鹏飞, 李平, 张潇, 王欣欣, 高媛媛, 李莉莉. 多肽类自组装纳米材料对抗细菌耐药的研究进展[J]. 应用化学, 2021, 38(5): 546-558.

LIU Jiao, ZOU Peng-Fei, LI Ping, ZHANG Xiao, WANG Xin-Xin, GAO Yuan-Yuan, LI Li-Li. Research Progress of the Peptide-Based Self-assembled Nanomaterials Against Microbial Resistance[J]. Chinese Journal of Applied Chemistry, 2021, 38(5): 546-558.

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