甘油作溶剂、微波促进苯并噁唑类化合物的合成

doi:10.11944/j.issn.1000-0518.2017.03.160243

摘要/Abstract

摘要：

苯并噁唑类化合物在医药、化工、有机合成等方面应用广泛,其合成具有重要意义。以邻氨基苯酚与苯甲醛类化合物为原料,物质量的比为1:1,用绿色试剂甘油做溶剂,微波加热促进合成苯并噁唑类化合物。聚焦微波功率为20 W,反应温度110 ℃。在此条件下,以80%~91%的产率得到相应的目标产物。该方法具有溶剂无污染、反应条件温和、操作简便、产率较高、反应底物易得,反应快速简便等优点,为现有方法提供了有益和重要的补充。

关键词: 苯并噁唑, 甘油, 邻氨基苯酚, 芳香醛

Abstract:

Benzoxazole derivatives are well known for their applications in medicinal, industrial and synthetic organic chemistry. Numerous effects has been focused on developing efficient methods for the synthesis of it. The benzoxazole derivatives was synthesised by condensation of 2-aminophenol and benzaldehyde in presence of glycerol under focused microwave-irradiation conditions. Reaction conditions:2-aminothiophenol(1.0 mmol), benzaldehyde(1.0 mmol), glycerol(2 mL), irradiating under focused microwave for several minutes at 20 W and 110 ℃. The corresponding products was obtained in 80% to 91% yield. The present method has the advantages of mild conditions, green solvent, simple operation, easily available reaction substrates, and excellent product yields, which make it a useful and important supplement to the existing methods.

Key words: benzoxazole, glycerol, aminophenol, aromatic aldehydes

雷蛟, 罗丽, 付维维, 周文俊. 甘油作溶剂、微波促进苯并噁唑类化合物的合成[J]. 应用化学, 2017, 34(3): 324-329.

LEI Jiao, LUO Li, FU Weiwei, ZHOU Wenjun. Microwave-Assisted Synthesis of Benzoxazoles in Glycerol[J]. Chinese Journal of Applied Chemistry, 2017, 34(3): 324-329.

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