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低取代度两亲性β-环糊精及其水相中纳米球的制备

郭文彦1,2,赵明刚1*,郝爱友3   

  1. (1.山西师范大学化学与材料科学学院 临汾 041004；2.山西师范大学现代文理学院 临汾 041000;
    3.山东大学化学与化工学院 济南 250100)
  • 收稿日期:2012-04-19 修回日期:2012-06-12 出版日期:2013-03-10 发布日期:2013-03-10
  • 通讯作者: 赵明刚，讲师; Tel:0357-2051192; E-mail:minggangzhao@hotmail.com; 研究方向：金属有机、有机合成和功能超分子
  • 基金资助:
    教育部高等学校博士学科点专项科研基金资助(20091404110001)

Synthesis of Amphiphilic β-Cyclodextrins and Their Nanospheres in Water

GUO Wenyan1,2, ZHAO Minggang1*, HAO Aiyou3   

  1. (1.School of Chemistry and Materials Science,Shanxi Normal University,Linfen 041004,China;
    2.Modern College of Arts and Science of Shanxi Normal University,Linfen 041000,China;
    3.School of Chemistry and Chemical Engineering,Shandong University,Ji′nan 250100,China)
  • Received:2012-04-19 Revised:2012-06-12 Published:2013-03-10 Online:2013-03-10

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摘要： 将2-O-(2-羟丙基)-β-环糊精与十二烷基、十四烷基、十六烷基和十八烷基缩水甘油醚在吡啶中反应，合成了4个低取代度的两亲性β-环糊精衍生物(平均取代度分别为1.87、1.95、2.14和1.80)。 将上述4个化合物分散于水中自组装成可稳定2~3周的纳米球，并且均呈现出较好的分散度和均匀性。

关键词: 两亲性, O-(羟丙基)-&, beta, -环糊精, 缩水甘油醚, 纳米球

Abstract: Four amphiphilic bifunctionalized β-cyclodextrin derivatives with low degree of substitution(DS) were conveniently synthesized via the reaction of 2-O-(2-hydroxypropyl)-β-cyclodextrin with Lauryl glycidol ether, tetradecyl glycidol ether, hexadecyl glycidol ether and octadecyl glycidol ether in pyridine, respectively. The four amphiphilic β-CD derivatives(DS 1.87, 1.95, 2.14 and 1.80, respectively) could self-assemble in water to form stable nanospheres with improved dispersion degree and uniformity up to 2~3 weeks.

Key words: amphiphilic, O-(hydroxypropyl)-&, beta, -cyclodextrin, glycidol ether, nanospheres

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