肝素钠/聚乙烯醇复合水凝胶的制备与性能

doi:10.11944/j.issn.1000-0518.2015.12.150228

摘要/Abstract

摘要：

通过循环冷冻-解冻法,制成了肝素钠/聚乙烯醇(HS/PVA)复合水凝胶材料。探讨了不同质量分数肝素钠对复合水凝胶材料的可见光透过率、含水率、亲水性、力学性能以及肝素钠释放量的影响。结果表明,复合水凝胶的可见光透过率为92%以上,溶胀平衡的含水率为72%~78%,亲水性较纯PVA水凝胶有所提升,拉伸强度和断裂伸长率都稍有下降。细胞粘附实验结果表明,适量的肝素钠的释放可以达到减少细胞粘附的效果。这种HS/PVA复合水凝胶材料有望用作人工角膜中心区材料。

关键词: 肝素钠, 聚乙烯醇, 复合水凝胶, 人工角膜, 细胞粘附

Abstract:

Heparin sodium/polyvinyl alcohol(HS/PVA) composite hydrogel was prepared successfully by the cyclic freezing-thawing method. Effects of mass fraction of heparin sodium on visible light transmittance, moisture content, hydrophilcity, mechanical property and percentage of heparin sodium release of composite hydrogel were studied. The results show that the introduction of heparin sodium into the structure of PVA can enhance the moisture content and hydrophilic of HS/PVA composite hydrogel, simultaneously, reduce visible light transmittance and mechanical properties of HS/PVA composite hydrogel. The release of heparin sodium from HS/PVA composite hydrogel resists the cell adhesion. Therefore, the HS/PVA composite hydrogel has a potential application in the fields of optical central materials of artificial cornea.

Key words: heparin sodium, polyvinyl alcohol, composite hydrogel, artificial cornea, cell adhesion

邓新旺, 胡惠媛, 罗仲宽, 吴茂盛, 周莉. 肝素钠/聚乙烯醇复合水凝胶的制备与性能[J]. 应用化学, 2015, 32(12): 1358-1363.

DENG Xinwang, HU Huiyuan, LUO Zhongkuan, WU Maosheng, ZHOU Li. Preparation and Properties of Heparin Sodium/Polyvinyl Alcohol Composite Hydrogel[J]. Chinese Journal of Applied Chemistry, 2015, 32(12): 1358-1363.

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