2,3-二芳基-1,3-苯并噁嗪的合成及杀菌活性

doi:10.11944/j.issn.1000-0518.2015.02.140191

摘要/Abstract

摘要：

在三甲基氯硅烷(TMSCl)的催化作用下,取代苯甲醛与邻(芳胺甲基)苯酚经N杂缩醛化反应生成了一系列2,3-二芳基-1,3-苯并噁嗪类化合物。目标化合物的结构用IR、¹H NMR、¹³C NMR和元素分析等技术手段进行了表征。对所合成的化合物进行了初步杀菌活性测试,部分表现出良好的杀菌活性,化合物6e对菌核病菌的抑制活性为79.0%,化合物6a和6d均为74.8%,化合物6e对灰霉病菌的抑制活性为77.9%。

关键词: 二芳基-苯并噁嗪, 合成, 杀菌活性

Abstract:

A series of 2,3-disubstituted-1,3-benzoxazines was synthesized by trimethyl chlorosilane-catalyzed aza-acetalization of 2-arylaminomethyl phenols with aromatic aldehydes. The structures of the prepared compounds were characterized by FT-IR, ¹H NMR, ¹³C NMR and elemental analysis. Fungicidal activities of these compounds were also evaluated. Most of them exhibit good activities. Compound 6e shows 79% and 77.9% activity against S.Scleratotiorum and B.Cinérea, respectively. Compounds 6a and 6d exhibit 74.8% activity against S.Scleratotiorum.

Key words: diaryl-benzoxazine, fungicidal activity

中图分类号:

O626

唐子龙, 夏赞稳, 王宏清, 王恋, 焦银春, 陈金文. 2,3-二芳基-1,3-苯并噁嗪的合成及杀菌活性[J]. 应用化学, 2015, 32(2): 143-150.

TANG Zilong, XIA Zanwen, WANG Hongqing, WANG Lian, JIAO Yinchun, CHEN Jinwen. Synthesis and Fungicidal Activities of 2,3-Diaryl-1,3-benzoxazines[J]. Chinese Journal of Applied Chemistry, 2015, 32(2): 143-150.

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