导尿管表面具有抗菌功能的层层组装微凝胶膜

doi:10.3724/SP.J.1095.2014.30617

摘要/Abstract

摘要： 以化学交联的聚烯丙基胺盐酸盐拟葡聚糖微凝胶和透明质酸为构筑基元，在导尿管表面层层组装构筑了厚度小于500 nm可控释放抗菌药物的聚合物微凝胶膜。广谱抗菌药物头孢曲松钠通过扩散吸附的方法在2 min内快速负载到聚合物微凝胶膜中，并且在生理盐水中可控释放时间达3 h。抗菌实验表明，组装有层层组装微凝胶膜并负载广谱抗菌药物的导尿管具有令人满意的抗菌效果，避免感染的发生。

关键词: 层层组装, 抗菌, 微凝胶, 导尿管

Abstract: The prevention of hospital-acquired infection attributable to indwelling urethral catheter use has recently received increased attention. For controlled release of antibacterial drugs, antibacterial films with a thickness less than 500 nm on urethral catheter were directly constructed by layer-by-layer deposition of poly(allylamine hydrochloride) and dextran(PAH-D) microgels with hyaluronic acid(HA). PAH-D/HA multilayer films can load negatively charged antibacterial drugs such as ceflriaxone sodium(CTX) in 2 min based on electrostatic interaction between PAH-D microgels and CTX molecules and then release them in 3 h in physiological saline. Direct deposition of microgel films and incorporation of CTX endow the multilayer micro films with an effective antibacterial performance.

Key words: Layer-by-layer assembly, Antibacterial, Microgel, Urethral catheter

中图分类号:

O631

王尊志, 张健夫, 陈栋栋. 导尿管表面具有抗菌功能的层层组装微凝胶膜[J]. 应用化学, DOI: 10.3724/SP.J.1095.2014.30617.

WANG Zunzhi1*, ZHANG Jianfu2, CHEN Dongdong2. Layer-by-Layer Assembled Antibacterial Microgel Films on Urethral Catheter[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30617.

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