中华医学超声杂志

应用化学 ›› 1998, Vol. 0 ›› Issue (2): 32-35.

• 研究论文 • 上一篇    下一篇

2,2-二取代-5-亚苄(糠)基环戊酮类化合物的合成及其生物活性

齐传民1, 陈万义2, 王文军2   

  1. 1. 北京师范大学化学系 北京100875;
    2. 中国农业大学应用化学系 北京100094
  • 收稿日期:1997-06-28 修回日期:1997-10-16 出版日期:1998-04-10 发布日期:1998-04-10
  • 基金资助:
    中国博士后科学基金

Synthesis and Biological Activity of 2,2-Disubstituted 5-Benzal(fural) Cyclopentanones

Qi Chuanmin1, Chen Wanyi2, Wang Wenjun2   

  1. 1. Department of Chemistry, Beijing Normal University, Beijing;
    2. Department of Applied Chemistry, China Agricultural University, Beijing 100094
  • Received:1997-06-28 Revised:1997-10-16 Published:1998-04-10 Online:1998-04-10

PDF

375

被引次数

1

摘要： 合成了18种2,2-二取代-5-亚苄(糠)基环戊酮类化合物,结构均通过核磁、红外、元素分析等予以确证。初步药理实验结果显示：该类化合物对鼻咽癌、结肠癌、卵巢癌和肺腺癌等癌细胞具有一定的抑制作用；某些化合物还有杀菌作用。

关键词: 亚苄(糠)基环戊酮, 合成, 抗癌活性, 杀菌活性

Abstract: Eighteen substituted cyclopentanones containing cyclopentenyl were synthesized. Their chemical structures were confirmed by elemental analysis, IR and 1H NMR measurements. The anticancer activities of the compounds have been examined. Compounds 2l, 2e and 2r were found to be active against KB, HCT, A2780, and A549 tumors in vitro. Compounds 2b and 2d showed activity only against HCT tumor. Compound 2e showed some fungistatic activity against plant pathogens in vitro.

Key words: benzal(fural) cyclopentanones, synthesis, anticancer, antifungal activity

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