应用化学 ›› 1998, Vol. 0 ›› Issue (1): 41-43.

• 研究论文 • 上一篇    下一篇

有机溶剂与氢化可的松的溶剂-溶质作用

汤志刚, 胡熙恩, 朱永(贝睿)   

  1. 清华大学核能技术设计研究院 北京 102201
  • 收稿日期:1997-04-02 修回日期:1997-08-15 出版日期:1998-02-10 发布日期:1998-02-10

Solvent-Solute Interaction between Hydrocortisone and Organic Solvents

Tang Zhigang, Hu Xi'en, Zhu Yongjun   

  1. Institute of Nuclear Energy Technology, Tsinhua University, Beijing 100084
  • Received:1997-04-02 Revised:1997-08-15 Published:1998-02-10 Online:1998-02-10

摘要: 通过测定氢化可的松在多种溶剂/水体系中的分配系数研究了氢化可的松与溶剂的相互作用机制.其中醇、酮与氢化可的松有较强的氢键作用,酯、醚、氯代烷烃等溶剂与氢化可的松的氢键作用较弱,四氯化碳、苯、环己烷不能与氢化可的松形成氢键.

关键词: 氢化可的松, 溶剂-溶质相互作用, 氢键, 分配系数

Abstract: The distribution coefficients of hydrocortisone in some solvent/water systems in-dicate that hydrocortisone has a stronger hydrogen bonds with alcohols and ketones, butcomparatively weak hydrogen bonds with esters, ethers and chlorocarbons.Hydrocortisonecan hardly form hydrogen bonding interaction with tetrachloromethane, benzene, and cyclo-hexane.

Key words: hydrocortisone, solvent-solute interaction, hydrogen bond, distribution coefficient