中华医学超声杂志

应用化学 ›› 1997, Vol. 0 ›› Issue (2): 96-98.

• 研究论文 • 上一篇    下一篇

取代苯基呋喃甲酸长链烷基酯的合成及生物活性

司宗兴, 孙亚秋, 汪海涛   

  1. 中国农业大学应用化学系, 北京 100094
  • 收稿日期:1996-06-17 修回日期:1996-12-05 出版日期:1997-04-10 发布日期:1997-04-10

Synthesis and Biological Activity of Long chain Esters of Substituted Phenyl α-Furoic Acid

Si Zongxing, Sun Yaqiu, Wang Haitao   

  1. Department of Applied Chemistry, China Agricultural University, Beijing 100094
  • Received:1996-06-17 Revised:1996-12-05 Published:1997-04-10 Online:1997-04-10

PDF

562

被引次数

6 | 3

摘要： 取代芳基呋喃甲酸是一类很好的活性基团, 它的酯在医学上用做镇痛剂[ 1]. 其它系列衍生物也有杀菌和镇痛活性[ 2]. 长链化合物也是一类具有广泛杀虫、杀菌及植物生长调节活性的物质[ 3], 其链的长短对活性有很大的影响. 作者根据结构活性关系, 把以上两个活性单元拼接在一起, 设计合成了未见报道的新取代苯基呋喃甲酸长链酯, 希望能改变作用靶标, 扩大作用谱, 以发现活性更好的杀菌剂。

关键词: 苯基呋喃甲酸酯, 合成, 杀菌活性

Abstract: Twenty novel long-chain esters of substituted phenyl α-furoic acid have been synthesized. Their structures were confirmed by IR, 1H NMR and elemental analysis. The preliminary biological activity experiments showed that a certainly definite length of the ester chain is profitable.

Key words: phenyl furoic acid ester, synthesis, antifungal activity

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