中华医学超声杂志

应用化学 ›› 1996, Vol. 0 ›› Issue (5): 106-108.

• 研究简报 • 上一篇    下一篇

3－芳基－1(2H,4H)－吖啶酮衍生物的合成及其镇痛作用

韩光范1, 魏永慧1, 尹荣1, 王进军2, 姜贵吉3   

  1. 1. 吉林医学院检验系 吉林 132001;
    2. 吉林化工学院精细化工系 吉林;
    3. 延边大学化学系 延吉
  • 收稿日期:1995-12-25 修回日期:1996-05-20 出版日期:1996-10-10 发布日期:1996-10-10

Synthesis and Analgesic Action of 3-Aryl-1(2H,4H)-Acridone Derivatives

Han Guangfan1, Wei Yonghui1, Yin Rong1, Wang Jinjun2, Jiang Guiji3   

  1. 1. Department of Medical Laboratory, Jilin Medical College, Jilin 132001;
    2. Department of Fine Chemistry, Jilin Chemical Industry Institute, Jilin;
    3. Department of Chemistry, Yanbian University, Yanji
  • Received:1995-12-25 Revised:1996-05-20 Published:1996-10-10 Online:1996-10-10

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摘要： 吖啶及吖啶酮类化合物具有抗疟、抗菌、抗炎和镇痛活性,特别是某些叮咤酮类化合物具有显著的抗癌活性.在我们的前期工作中已经合成了一些能够显著抑制从口腔癌中分离出来的KB细胞生长的叮吮酮类化合物.为了寻求新的叮咤酮类药物,以邻氨基苯甲醛为原料合成了一些新的3-芳基-1(2H,4H)-叮咤酮及其衍生物.并采用抑制扭体法进行了镇痛活性试验.

关键词: 吖啶酮衍生物, 合成, 镇痛作用

Abstract: Aryl-1(2H, 4H)-acridones and the related acridine-fused pyridine and pyrimidines were synthesized. The structures of all compounds obtained were characterized by elemental analysis, IR and 1H NMR spectra. Some of the compounds show significant analgesic activity.

Key words: derivative of acridone, synthesis, analgesic activity

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