中华医学超声杂志

应用化学 ›› 1993, Vol. 0 ›› Issue (6): 86-88.

• 研究简报 • 上一篇    下一篇

1-取代苯基-1,4-二氢-6-甲基-4-哒嗪酮-3-酰胺的合成

李正名, 邹霞娟, 么恩云, 王素华   

  1. 南开大学元素有机化学研究所 300071 天津
  • 收稿日期:1993-02-18 修回日期:1993-05-17 出版日期:1993-12-10 发布日期:1993-12-10
  • 基金资助:
    国家自然科学基金资助课题

SYNTHESES OF 1-ARYL-1,4-DIHYDRO-6-METHYL-4-PYRIDAZONE-3-AMIDES

Li Zhengming, Zhou Xiajuan, Yao Enyun, Wang Suhua   

  1. Elemento-Organic Chemistry Institute, Nankai University, 300071 Tianjin
  • Received:1993-02-18 Revised:1993-05-17 Published:1993-12-10 Online:1993-12-10

PDF

436

被引次数

3

摘要： 用杂交方法培育新作物品种是农业增产的重要措施。与常规杂交育种方法相比,采用化学杀雄法(Chemical induction lf male sterility)育种具有程序简单,节省劳力,时间缩短等优点,可以诱导产生非遗传性的雄性不育母本,与另一品种的文本杂交而得优化组合的良种,国外在小麦上已试验成功但在水稻上尚在探索,美国Rohm and Haas公司曾报道一些哒嗪酮类具有化学杀雄活性。本文合成了15个新哒嗦酮类衍生物,其结构均经IR,NMR,MS及元素分析确定。

关键词: 哒嗪酮, 化学杀雄剂, 合成

Abstract: α-Methyl pyrazones have been reacted with aryl diazonium salts to form 3-arylhy-drazones-6-methyl-2,4-dioxopyranones,which are converted to 1-aryl-6-methyl-4-oxo-pyri-dazinone-3-carboxylic acids by cyclization. A series of 4-pyridazinone-3-amides were obtained by reacting the carboxylic acids with ethylchlorocarboxylate and corresponding amines. The structures of new compounds thus obtained were checked by elemental analyses,IR,NMR and MS measurements.

Key words: pyridazinone, chemical induction agent of male sterility, synthesis

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