中华医学超声杂志

应用化学 ›› 1993, Vol. 0 ›› Issue (1): 12-15.

• 研究论文 • 上一篇    下一篇

栗甾酮A/B环类似物的合成研究 Ⅱ.2β,3β-二羟基-6-胆甾酮的立体选择性合成

高碧1, 王植材1, 郑其煌1, 许志文2   

  1. 1. 中山大学化学系 510275 广州;
    2. 厦门大学化学系 厦门
  • 收稿日期:1992-03-03 修回日期:1992-06-24 出版日期:1993-02-10 发布日期:1993-02-10

STUDIES ON SYNTHESIS OF A/B RING ANALOGUES OF CASTASTERONE Ⅱ.STEREOSELECTIVE SYNTHESIS OF 2β,3β-DIHYDROXY-6-CHOLESTERONE

Gao Bi1, Wang Zhicai1, Zheng Qihuang1, XU Zhiwen2   

  1. 1. Department of Chemistry, Zhongshan University, 510275 Guangzhou;
    2. Department of Chemistry, Xiamen University, Xiamen
  • Received:1992-03-03 Revised:1992-06-24 Published:1993-02-10 Online:1993-02-10

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摘要： 以胆甾醇为原料,经硝化、还原、消除等反应以及用I2-AgOAc-H2O氧化引进2β,3β-二羟基的方法,立体选择性地合成了具有栗甾酮A/B环结构单元的类似物2β,3β-二羟基-6-胆甾酮。'eh

关键词: 2β,3β-二羟基胆甾酮, 栗甾酮, A/B环类似物, I2-AgOAc氧化, 合成

Abstract: 2β, 3β-Dihydroxy-6-cholesterone, a structural analogue in A/B rings of castasterone was stereoselectively synthesized from cholesterol via nitration, reduction; elimination and oxidation reactions. The key step in the synthesis is the introduction of 2β, 3β-dihydroxy groups by oxidation with I2-AgOAe-H2O.

Key words: 2β, 3β-dihydroxycholesterone, castasterone, A/B ring analogue, I2-AgOAc oxidation, synthesis

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