中华医学超声杂志

应用化学 ›› 1992, Vol. 0 ›› Issue (2): 83-85.

• 研究简报 • 上一篇    下一篇

中长碳链α-氯代脂肪酸的合成

成本诚, 夏鹏飞, 彭卫红   

  1. 中南工业大学化学系, 长沙 410083
  • 收稿日期:1991-03-13 修回日期:1991-05-27 出版日期:1992-04-10 发布日期:1992-04-10

SYNTHESIS OF MID-LONG CHAIN α-CHLOROALIPHATIC ACIDS

Cheng Bencheng, Xia Pengfei, Peng Weihong   

  1. Department of Chemistry, Central South University of Technology, Changsha 410083
  • Received:1991-03-13 Revised:1991-05-27 Published:1992-04-10 Online:1992-04-10

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426

摘要： Hell-Volhard-Zelinsky反应仅对羧酸的α-溴化有高的选择性,而沿用到α-氯化则产生β,γ或α,α-二氯代羧酸等难以分离的副产物。早年曾用烷基丙二酸与硫酰氯反应然后脱羧制得C4到C12的α-氯代直链脂肪酸。该法若以丙二酸酯为原料,不仅全程总产率低,

关键词: α-氯代脂肪酸, 合成

Abstract: Four mid-long chain a-chloroaliphatic acids(C8, C10,C12) were synthesized in 50～70% yield. Their physical and chemical constants, IR and 1H NMR spectra data were determined. The method has a good specifity, without any α,α-dichloro-, β-and γ-chloro-acids as by products.

Key words: α-chloroaliphatic acid, synthesis

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