中华医学超声杂志

应用化学 ›› 1989, Vol. 0 ›› Issue (3): 57-58.

• 研究简报 • 上一篇    下一篇

β,γ-不饱和酰胺合成新方法

李朝军1, 李纪生1, 陈德恒2   

  1. 1. 中国科学院化学研究所 北京;
    2. Deparment of Chemistry, McGill University, Canada
  • 收稿日期:1988-07-13 修回日期:1988-10-14 出版日期:1989-06-10 发布日期:1989-06-10

A NEW METHOD FOR SYNTHESIS OF β,γ-UNSATURATED AMIDES

Li Chaojun1, Li Jisheng1, Chen Deheng2   

  1. 1. Institute of Chemistry, Academia Sinica, Beijing;
    2. Department of Chemistry, McGill University, Canada
  • Received:1988-07-13 Revised:1988-10-14 Published:1989-06-10 Online:1989-06-10

PDF

387

摘要： α-芳基和α-烯基羰基结构是一类天然生物分子的重要特征结构.我们曾用二烷基烯烃基铝同α-卤代酸酯反应立体选择性地合成β,γ-不饱和酸酯.本文通过二烷基烯烃基铝与丁基锂形成的酸根型配合物,与α-卤代酰胺反应制备β,γ-不饱和酰胺.

关键词: 不饱和酰胺, 烯基铝, 合成, 酸根型配合物

Abstract: Reaction of vinylalanate obtained from the readily available. dialkylvinylalane and n-butyl lithium with α-halo-amides produced the corresponding β,γ-unsaturated amides, withclean retention of the configuration. The yields were 35% to 70%.

Key words: Unsaturated amide, Vinylalane, Synthesis, Ate-complex

网站版权 © 应用化学     本网站备案：吉ICP备12000082号