应用化学 ›› 2011, Vol. 28 ›› Issue (04): 367-375.DOI: 10.3724/SP.J.1095.2011.00364

• 综合评述 • 上一篇    下一篇

小分子抗原人工合成进展

王建华*,张冲   

  1. (重庆大学生物工程学院 重庆 400044)
  • 收稿日期:2010-06-24 修回日期:2010-09-06 出版日期:2011-04-10 发布日期:2011-04-10
  • 通讯作者: 王建华,教授; Tel:023-65102507; Fax:023-65103031; E-mail:wjh@cqu.edu.cn; 研究方向:药物合成及制剂工程
  • 作者简介:通讯联系人:王建华,教授;电话023-65102507;传真:023-65103031;E-mail:wjh@cqu.edu.cn;研究方向:药物合成及制剂工程
  • 基金资助:
    国家科技支撑计划(2007BAD51B05)

Recent Progress in Synthetic Methods of Small Molecule Antigen

WANG Jianhua*, ZHANG Chong   

  1. (College of Biomedical Engineering,Chongqing University,Chongqing 400044)
  • Received:2010-06-24 Revised:2010-09-06 Published:2011-04-10 Online:2011-04-10
  • Contact: Jianhua

摘要:

小分子免疫分析技术的应用日渐广泛,合成稳定的、具有良好免疫原性的人工抗原是制备单克隆抗体和建立免疫分析方法的前提和关键。 本文对国内外半抗原的设计与合成方法、载体的选择、半抗原与载体的耦联方法等进行了综述,并对小分子抗原人工合成中相关的问题进行了讨论。

关键词: 人工抗原, 半抗原, 合成, 免疫分析

Abstract:

With increasing applications of immune assay, the synthesis of artificial antigen with good stability and immunogenic is the key and premise to prepare the antibody and to establish the method for small molecule immune assay. The progress of synthesis and design method of hapten, carrier selection and the couple method of hapten with carrier are reviewed in this paper. In addition, some questions of the synthesis of small molecule artificial antigen were also discussed.

Key words: artificial antigen, hapten, synthesis, immune assay

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