中华医学超声杂志

应用化学 ›› 2011, Vol. 28 ›› Issue (02): 149-153.DOI: 10.3724/SP.J.1095.2011.00224

• 研究论文 • 上一篇    下一篇

两亲性杂壳聚合物粒子的高效制备及以其作为模板合成金纳米簇合物

程林*,王凤洋   

  1. (安徽师范大学化学与材料科学学院，安徽省分子基材料重点实验室，功能性分子固体重点实验室 芜湖 241000)
  • 收稿日期:2010-04-15 修回日期:2010-08-04 出版日期:2011-02-10 发布日期:2011-02-10
  • 通讯作者: 程林，副教授; E-mail:chenglin@mail.ahnu.edu.cn; 办公电话/传真：0553-3869303; 研究方向：高分子化学与物理
  • 基金资助:
    国家自然科学基金（20904001）安徽省自然科学基金（090414198）资助项目

Amphiphilic Mixed-Shell Polymeric Nanoparticles:Efficient Synthesis and Use as Template for Preparing Gold Nanoclusters

CHENG Lin*, WANG Feng-Yang   

  1. (College of Chemistry and Materials Science,Anhui Key Laboratory of Molecule-Based Materials,
    Anhui Key Laboratory of Functional Molecular Solids,Anhui Normal University,Wuhu 241000)
  • Received:2010-04-15 Revised:2010-08-04 Published:2011-02-10 Online:2011-02-10

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摘要：

将等质量的嵌段聚合物聚乙烯基萘聚丙烯酸和聚氧化乙烯聚丙烯酸（P2VN-b-PAA和PEO-b-PAA）溶解于N,N′-二甲基甲酰胺(DMF)中，加入小分子二元胺（1，2-丙二胺,PDA），制备出均匀的两亲性杂壳聚合物纳米粒子(MSNPs)。 该粒子以PEO和P2VN混合嵌段为壳层，非共价键交联的PAA嵌段为核，在水相及有机相中均可稳定分散，具有典型的两亲性特点。 扫描电子显微镜和光散射测试结果表明，该杂壳聚合物粒子(MSNPs)的粒径在300 nm左右，分布较均匀，并显示出壳层可塌缩变形的疏松核（软粒子）特征。 以该聚合物粒子(MSNPs)为模板，可以方便制备出金纳米粒子簇合物。

关键词: 两亲性纳米粒子, 嵌段聚合物, 组装, 纳米簇合物

Abstract:

Amphiphilic mixedshell polymeric nanoparticles(MSNPs) were synthesized efficiently by non-covalently-cross-linking of two diblock copolymers(1∶1 mass ratio) of poly(ethylene oxide)-b-poly(acrylic acid)(PEO-b-PAA) and poly(2-vinylnaphthalene)-b-poly-(acrylic acid)(P2VN-b-PAA) with 1,2-propane diamine(PDA) in DMF. In such amphiphilic MSNPs, the shell consisted of poly-(2-vinyl naphthalene)(P2VN)/polyethylene oxide(PEO) while the core was formed from noncovalently cross-linked poly(acrylic acid)(PAA). The MSNPs could disperse in water and DMF without coalescence due to their distinct amphiphilic nature. The flexible cores of MSNPs were confirmed by SEM and FTIR. Dynamic light scattering result showed that the diameter of the amphiphlic MSNP was about 300 nm. The shells of the MSNPs could collapse in solid state resulted in their flexible cores. The MSNPs could be used as template for preparing gold nanoclusters in water.

Key words: amphiphilic nanoparticle, block copolymer, assembly, nanocluster

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