关键词: 去氢表雄酮, 3β-羟基雄甾烯二酮, 合成

Abstract:

Dehydroepiandrosterone was oxidized with PCC to obtain androst-4-en-3,6,17-rione(2), which was then submitted to reduction with NaBH4 in the presence of Co2+ to obtain 3β-hydroxyandrost-4-en-6,17-dione(3), a nonandrogenic aromatase inhibitor. Compared with literature′s methods, this method shortens the reaction steps and improves the reaction yield. The structure of compound 3 was characterized by NMR and IR.

Key words: dehydroepiandrosterone, 3β-hydroxyandrost-en-dione, synthesis