中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (03): 347-352.DOI: 10.3724/SP.J.1095.2010.90299

• 研究论文 • 上一篇    下一篇

CDMPC手性固定相对新型金属簇化合物的手性拆分

陈丽梅1,3,杨晶沐1,2,3,刘霞1*,蒋生祥1   

  1. (1.中国科学院兰州化学物理研究所甘肃省天然药物重点实验室 兰州 730000；
    2.中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室 兰州；3.中国科学院研究生院 北京)
  • 收稿日期:2009-04-20 修回日期:2009-07-21 出版日期:2010-03-10 发布日期:2010-03-10
  • 通讯作者: 刘霞，女，研究员; E-mail:gsliuxia@lzb.ac.cn; 研究方向：液相色谱及相关技术
  • 基金资助:
    国家自然科学基金（20775084，20875096）和甘肃省技术支撑项目（0804GKCA034）资助项目

Enantioseparation of novel metal clusters using CDMPC chiral stationary phase

CHEN Li-Mei1,3, YANG Jing-Mu1,2,3, LIU Xia1*, JIANG Sheng-Xiang1   

  1. (1.Key Laboratory for Natural Medicine of Gansu Province,Lanzhou Institute of
    Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000;
    2.State key laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute
    of Chemical Physics,Chinese Academy of Sciences,Lanzhou;
    3.Graduate School of Chinese Academy of Sciences,Beijing)
  • Received:2009-04-20 Revised:2009-07-21 Published:2010-03-10 Online:2010-03-10
  • Contact: Xia Liu

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摘要：

应用纤维素三（3，5-二甲基苯基氨基甲酸酯）（cellulose tris (3, 5- dimethylphenylcarbamate，CDMPC）手性固定相对两种新型金属簇合物进行了拆分,通过流动相组成、流速和样品溶剂等条件对拆分影响的考察进行了拆分条件的优化。实验结果表明，簇合物1和簇合物2分别在含乙醇V(hexane)∶V(ethanol)=95∶5)和异丙醇(V(hexane)∶V(2-propanol)=90∶10)的流动相中得到了较好的拆分，将样品溶解在和流动相组成相近的溶剂中更利于簇合物拆分，簇合物配体结构对簇合物在固定相上的保留和拆分有重要的影响。 在优化条件下，2种金属簇合物分离度均达到1.5以上。

关键词: 金属簇合物, CDMPC, 手性拆分, 液相色谱

Abstract:

Two novel(carbonyl) triruthenium metal clusters were separated with cellulose tris(3,5dimethylphenylcarbamate)(CDMPC) as chiral stationary phase. The effects of the optimal conditions were determined according to the effects of the mobile phase composition, the flow rate of the mobile phase and the solvents of the samples etc on the chiral separation of the metal clusters. The results show that good chiral separations of cluster 1 and cluster 2 were obtained respectively using the mobile phase with ethanol(V(hexane)∶V(ethanol)=95∶5) and 2-propanol(V(hexane)∶V(2-propanol)=90∶10). The solvents of the samples with similar composition to that of the mobile phase were beneficial to the chiral separation of the clusters. The structures of the metal-chelated ligand exerted an important influence on the retention and chiral separation of the metal clusters. The Rs of the clusters were above 1.5 under the optimal conditions.

Key words: Novel metal clusters, CDMPC, Chiral separation, HPLC

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