甲醇和乙醇在氩气-实时直接分析质谱中的应用

doi:10.11944/j.issn.1000-0518.2017.06.160392

摘要/Abstract

摘要：

以氩气代替价格昂贵的氦气作为实时直接分析质谱(DART-MS)的工作气体以降低实验成本。甲醇和乙醇作为作为两种辅助性反应试剂,在Ar-DART-MS分析中充当能量传递的媒介和质子的供体,可以提高Ar-DART-MS的电离效率并扩展其应用范围。通过甲醇和乙醇作为反应性试剂在Ar-DART-MS的背景信号及对样品电离影响的分析,探讨了它们的应用范围,以及在电离过程中存在的一些可能的特征反应。该方法的有效性通过对利血平的分析结果获得。

关键词: 实时直接分析质谱, 氩气, 甲醇, 乙醇

Abstract:

In this research, argon was used as the running gas in direct analysis in real time mass spectrometry instead of helium in order to reduce the cost of experiment. Methanol and alcohol as reactive reagents improve the ionization efficiency of analytes and expand the application of Ar-DART-MS. This is because the above reagents play important roles as the medium of the energy transferring and the domor of proton in Ar-DART-MS analysis. Through the analysis of background signal from methol and alcohol as reactive reagents in Ar-DART-MS and their affect on sample ionization, the application scope of methanol and alcohol as reactive reagents in Ar-DART-MS was discussed. Some possible characteristic reactions were also explored. The validity of this method was verified by the analysis of reserpine.

Key words: direct analysis in real time mass spectrometry, argon, methanol, alcohol

周峰, 刘舒, 刘志强, 宋凤瑞. 甲醇和乙醇在氩气-实时直接分析质谱中的应用[J]. 应用化学, 2017, 34(6): 729-732.

ZHOU Feng, LIU Shu, LIU Zhiqiang, SONG Fengrui. Application of Methanol and Ethanol in Argon-Direct Real Time Mass Spectrometry Analysis[J]. Chinese Journal of Applied Chemistry, 2017, 34(6): 729-732.

参考文献

[1]	Cody R B,Larame'e J A,Durst H D. Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions[J]. Anal Chem,2005,77(8):2297-2302.
[2]	Takats Z,Wiseman J M,Gologan B,et al. Mass Spectrometry Sampling under Ambient Conditions with Desorption Electrospray Ionization[J]. Science,2004,306(5695):471-474.
[3]	Song L G,Gibson S C,Bhandari D,et al. Ionization Mechanism of Positive-Ion Direct Analysis in Real Time:A Transient Microenvironment Concept[J]. Anal Chem,2009,81(24):10080-10088.
[4]	Gross J H. Direct Analysis in Real Time-A Critical Review on DART-MS[J]. Anal Bioanal Chem,2014,406(1):63-80.
[5]	Harris G A,Falcone C E,Fernández F M. Sensitivity “Hot Spots” in the Direct Analysis in Real Time Mass Spectrometry of Nerve Agent Simulants[J]. J Am Soc Mass Spectrom,2012,23(1):153-161.
[6]	CHEN Huanwen,HU Bin,ZHANG Xie. Fundamental Principles, Practical Applications of Ambient Ionization Mass Spectrometry for Direct Analysis of Complex Samples[J]. Chinese J Anal Chem,2010,38(8):1069-1088(in Chinese). 陈焕文,胡斌,张燮. 复杂样品质谱分析技术的原理与应用[J]. 分析化学,2010,38(8):1069-1088.
[7]	ZHANG Jialing,HUO Feifeng,ZHOU Zhigui,et al. The Principles and Application of an Ambient Ionization Method-Direct Analysis in Real Time(DART)[J]. Prog Chem,2012,24(1):101-109(in Chinese). 张佳玲,霍飞凤,周志贵,等. 实时直接分析质谱的原理及应用[J]. 化学进展,2012,24(1):101-109.
[8]	Dane A J,Cody O B. Selective Ionization of Melamine in Powdered Milk by Using Argon Direct Analysis in Real Time(DART) Mass Spectrometry[J]. Analyst,2010,135:696-699.
[9]	Ding X L,Zhan X F,Yuan X,et al. Microfabricated Glow Discharge Plasma(MFGDP) for Ambient Desorption/Ionization Mass Spectrometry[J]. Anal Chem,2013,85(19):9013-9020.
[10]	Abedi A,Sattar L,Gharibi M,et al. Ions in He, Ar, N2, and CO2[J]. Int J Mass Spectrom,2014,370:101-106.
[11]	Cody R B. Observation of Molecular Ions and Analysis of Nonpolar Compounds with the Direct Analysis in Real Time Ion Source[J]. Anal Chem,2009,81(3):1101-1107.
[12]	Kratzer J,Mester Z,Sturgeon R E. Comparison of Dielectric Barrier Discharge, Atmospheric Pressure Radiofrequency-driven Glow Discharge and Direct Analysis in Real Time Sources for Ambient Mass Spectrometry of Acetaminophen[J]. Spectrochim Acta Part B,2011,66(8):594-603.
[13]	DAI Chunmei,WANG Jiabo,KONG Weijun,et al. Investigation on the Antibacterial Activity of Coptischinensis Franch and Its Components Compatibility by Microcalorimetry[J]. Acta Chim Sin,2010,68(10):936-940(in Chinese). 代春美,王伽伯,孔维军,等. 微量热法研究黄连及其主要组分配伍的抑菌作用[J]. 化学学报,2010,68(10):936-940.

[1]	张丹, 尚润梅, 赵振涛, 李君华, 邢锦娟. V/Ce-Al₂O₃催化甲醇选择性氧化制备二甲氧基甲烷[J]. 应用化学, 2022, 39(9): 1429-1436.
[2]	吴雪婷, 于洋, 宋术岩, 张洪杰. 人工固碳技术—热催化还原CO₂催化剂的研究进展[J]. 应用化学, 2022, 39(4): 599-615.
[3]	孙立智, 吕浩, 闵晓文, 刘犇. 介孔钯-硼合金纳米颗粒的制备和甲醇氧化电催化性能[J]. 应用化学, 2022, 39(4): 673-684.
[4]	田舒阳, 吕荣文. 氧化镁载金钯双金属无溶剂催化氧化苯甲醇制备苯甲醛[J]. 应用化学, 2021, 38(7): 789-799.
[5]	乔宗文, 陈涛. 具有高效长侧链的芘磺酸型磺化聚砜阳离子交换膜的性能[J]. 应用化学, 2021, 38(6): 668-674.
[6]	黄婕颖, 刘建军, 左胜利, 韩文静, 于迎春. Ag₃PO₄量子点/石墨相氮化碳纳米片复合光催化剂的制备及其对苯甲醇选择性氧化活性[J]. 应用化学, 2020, 37(9): 1030-1037.
[7]	苗中硕,门永锋. 快速扫描量热法研究聚对苯二甲酸-1,4-环己烷二甲醇酯的结晶和熔融行为[J]. 应用化学, 2020, 37(6): 642-649.
[8]	高佳, 宋夫交, 程文强, 葛艳, 许琦. Pd-Cu/ZrO₂催化CO₂加氢制甲醇的性能[J]. 应用化学, 2020, 37(2): 160-167.
[9]	胡学一, 罗敏敏, 方云, 李俊国, 孙洋, 李华山. 乙醇胺类原料形成亚硝胺的比较[J]. 应用化学, 2019, 36(9): 1061-1068.
[10]	胡学一, 罗敏敏, 方云, 李俊国, 孙洋, 李华山. 乙醇胺类原料形成亚硝胺的比较[J]. 应用化学, 2019, 36(9): 0-.
[11]	刘宗章,张彤,徐彧超,姜浩锡,张敏华. 乙醇制1,3-丁二烯MgO/SBA-15催化剂的制备及其催化性能[J]. 应用化学, 2019, 36(2): 176-181.
[12]	邓光荣, 梁亮, 李晨阳, 刘长鹏, 葛君杰, 邢巍. 直接甲醇燃料电池甲醇传质过程分析及浓度控制策略[J]. 应用化学, 2019, 36(10): 1211-1220.
[13]	孙墨杰, 吕涛, 徐维林. 微流控合成高活性甲醇氧化碳载铂钌电催化剂[J]. 应用化学, 2018, 35(5): 564-573.
[14]	孙墨杰, 吕涛, 徐维林. 微流控合成高活性甲醇氧化碳载铂钌电催化剂[J]. 应用化学, 2018, 35(5): 0-0.
[15]	唐子龙, 谭经照, 蔡兰琼, 李新兴, 刘万强. 新型2-(芳氨基乙基氨基)苯甲醇的合成及其杀菌活性[J]. 应用化学, 2017, 34(3): 345-353.