氯丙嗪分子印迹敏感膜传感器的制备与应用

doi:10.3724/SP.J.1095.2013.30030

摘要/Abstract

摘要： 以氯丙嗪为模板分子，邻氨基酚为功能单体，在金电极表面电聚合制备具有特异性识别孔穴的氯丙嗪分子印迹敏感膜(MIP)。采用循环伏安法(CV)、差分脉冲伏安法(DPV)等研究了印迹膜的性能、结构和分子印迹效应，并与其结构相似的化合物奋乃静和异丙嗪的选择性响应进行了比较，发现传感器对氯丙嗪具有良好的选择性。氯丙嗪浓度在6.0×10-7～9.0×10-5 mol/L范围内与峰电流呈线性关系，线性方程为:I(μA)=61.25lg c(μmol/L)+23.47(r=0.9975)，根据DL=3δb/s计算检出限为2.0×10-7 mol/L，该传感器具有良好的重复性、再生性和高灵敏度。

关键词: 氯丙嗪, 分子印迹, 电化学传感器, 电聚合

Abstract: A sensitive chlorpromazine sensor based on molecularly imprinted membrane(MIP) was fabricated with chlorpromazine as template molecule and o-aminophenol as functional monomers. The performance of MIP and the electrochemical behavior of molecular imprinted sensor were obtained by cyclic voltammetry(CV) and differential pulse voltammetry(DPV). The sensor exhibits good selectivity and sensitivity for measuring chlorpromazine compared with the structurally-related compounds of promethazine and perphenazine. The linear relationship between the peak current and chlorpromazine concentration is found at the range of 6.0×10-7～9.0×10-5 mol/L, the liner equation is I(μA)=61.25lg c(μmol/L)+23.47(r=0.9975), the limit of detection is 2.0×10-7 mol/L. This sensor has many advantages such as high sensitivity, good reproducibility and repeatability.

Key words: chlorpromazine, molecularly imprinting, electrochemical sensor, electropolymerization

中图分类号:

O657.3

刘蓉, 钟桐生, 龙立平, 尹志芳, 曹伟. 氯丙嗪分子印迹敏感膜传感器的制备与应用[J]. 应用化学, DOI: 10.3724/SP.J.1095.2013.30030.

LIU Rong, ZHONG Tongsheng*, LONG Liping, YIN Zhifang, CAO Wei. Fabrication and Application of Chlorpromazine Molecular Imprinting Film Sensor[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2013.30030.

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