基于纳米金增敏的双酚A二氧化钛凝胶分子印迹电化学传感器的制备及应用

doi:10.11944/j.issn.1000-0518.2018.04.170107

摘要/Abstract

摘要：

以纳米金(AuNPs)为增敏材料,双酚A(BPA)为模板分子,结合表面溶胶凝胶法和自组装法,制备了BPA纳米金-TiO₂凝胶分子印迹电化学传感器。利用扫描电子显微镜和能谱对AuNPs进行了表征,利用红外光谱仪对TiO₂凝胶、BPA以及BPA印迹TiO₂凝胶进行表征。在最优条件下,该传感器对BPA在1.0×10^-8~1.0×10^-5 mol/L浓度范围内具有良好的线性关系,线性相关系数为0.995,检测限为0.6×10^-8mol/L,并将该分子印迹传感器应用于实际样品中BPA的分析检测,其回收率为97.4%~103%。

关键词: 纳米金, 双酚A, TiO₂, 溶胶凝胶法, 自组装法, 分子印迹传感器

Abstract:

A bisphenol-A(BPA) TiO₂ gel molecularly imprinted electrochemical sensor was fabricated using gold nanoparticles(AuNPs) as sensitivity-enhanced materials based on surface sol-gel and self-assembly methods. AuNPs were characterized by scanning electron microscopy(SEM) and energy dispersive spectroscopy. BPA, TiO₂ gel, and BPA-imprinted TiO₂ gel were characterized by Fourier transform infrared(FTIR) spectrometry. Under optimal conditions, the sensor exhibits a good linear response from 1.0×10^-8 to 1.0×10^-5 mol/L for bisphenol A, with correlation coefficient 0.995 and a low detection limit of 0.6×10^-8 mol/L(S/N=3). The prepared sensor was successfully applied in the detection of actual sample with 97.4%~103% recoveries.

Key words: gold nanoparticles, bisphenol A, TiO₂, sol-gel method, self-assembly method, molecularly imprinted sensor

李玲玲, 杨绍明, 丁绍卿, 尚培玲, 杨杰, 曹嫱, 查文玲. 基于纳米金增敏的双酚A二氧化钛凝胶分子印迹电化学传感器的制备及应用[J]. 应用化学, 2018, 35(4): 484-490.

Lingling LI, Shaoming YANG, Shaoqing DING, Peiling SHANG, Jie YANG, Qiang CAO, Wenling ZHA. Preparation and Application of Bisphenol-A TiO₂ Gel Molecularly Imprinted Electrochemical Sensor Based on the Sensitivity-Enhancement of Gold Nanoparticles[J]. Chinese Journal of Applied Chemistry, 2018, 35(4): 484-490.

参考文献

[1]	Andreescu S,Sadik O A.Correlation of Analyte Structures with Biosensor Responses Using the Detection of Phenolic Estrongens as a Model[J]. Anal Chem,2004,76(3):552-560.
[2]	Andersson L I,Mandenius C F,Mosbach K.Studies on Guest Selective Molecular Recognition on an Octadecyl Silylated Silicon Surface Using Ellipsometry[J]. Tertrahydron Lett,1988,29(42):5437-5440.
[3]	Ichinose I,Senzu H,Kunitake T.A Surface Sol-Gel Process of TiO2 and Other Metal Oxide Films with Molecular Precision[J]. Chem Mater,1997,9(6):1296-1298.
[4]	Ichinose I,Kawakami T,Kunitake T.Alternate Molecular Layers of Metal Oxides and Hydroxyl Polymers Prepared by the Surface Sol-Gel Process[J]. Adv Mater,1998,10(7):535-539.
[5]	Yonezawa T,Matsune H,Kunitake T.Layered Nanocomposite of Close-Packed Gold Nanoparticles and TiO2 Gel Layers[J]. Chem Mater,1999,11(1):33-35.
[6]	Zhang C J,Yan J L,Zhang C X,et al. Enhanced Adsorption of Atrazine from Aqueous Solution by Molecularly Imprinted TiO2 Film[J]. Solid State Sci,2012,14(7):777-781.
[7]	Mujahid A,Lieberzeit P A,Dickert F L.Chemical Sensors Based on Molecularly Imprinted Sol-Gel Materials[J]. Materials,2010,3(4):2196-2217.
[8]	Rachna R,Sheetal C,Tulika D,et al. Development of an Amperometric Sulfite Biosensor Based on a Gold Nanoparticles/Chitosan/Multiwalled Carbon Nanotubes/Polyaniline-Modified Gold Electrode[J]. Anal Bioanal Chem,2011,401(8):2599-2608.
[9]	Kong F Y,Xu M T,Xu J J,et al. A Novel Lable-free Electrochemical Immunosensor for Carcinoembryonic Antigen Based on Gold Nanoparticles-Thionine-Reduced Graphene Oxide Nanocomposite Film Modified Glassy Carbon Electrode[J]. Talanta,2011,85(5):2620-2625.
[10]	YANG Shaoming,ZHA Wenling,SUN Qing,et al. Lable-Free Electrochemical Aptasensor Based on Nickel Hexacyanoferrate for the Detection of Thrombin[J]. Chinese J Appl Chem,2014,31( 6):743-748(in Chinese). 杨绍明,查文玲,孙清,等. 基于铁氰化镍的非标记型核酸适配体电化学传感器检测凝血酶[J]. 应用化学,2014,31(6):743-748.
[11]	Li N,Fan X,Tang K,et al. Nanocomposite Scaffold with Enhanced Stability by Hydrogen Bonds Between Collagen, Polyvinyl Pyrrolidone and Titanium Dioxide[J]. Colloid Surf B,2016,140:287-296.

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