中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (01): 53-57.

• 研究论文 • 上一篇    下一篇

以水作溶剂微波法合成1,4-二氢苯并咪唑并[1，2-a]嘧啶类衍生物

崔永涛,王建强,殷俊,季春香,郭成*   

  1. (南京工业大学理学院 南京 210009)
  • 收稿日期:2009-01-15 修回日期:2009-05-04 出版日期:2010-01-10 发布日期:2010-01-10
  • 通讯作者: 郭成，男，博士，教授; E-mail:guocheng@njut.edu.cn; 研究方向：精细有机合成

Synthesis of 1,4-dihydropyrimido[1,2-a]benzimida-zole derivatives via Microwave in the solutions of water

CUI Yong-Tao, WANG Jian-Qiang, YIN Jun, JI Chun-Xiang, GUO Cheng*   

  1. (College of Sciences,Nanjing University of Technology,Nanjing 210009)
  • Received:2009-01-15 Revised:2009-05-04 Published:2010-01-10 Online:2010-01-10
  • About author:Corresponding author: Guo Cheng, Doctor, Professor, E-mail: guocheng@njut.edu.cn; Research direction: Fine organic synthesis

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摘要：

以芳香醛、2-氨基苯并咪唑和丙二腈为原料，用传统法和微波辐射方法三组分一锅煮法合成1,4-二氢苯并咪唑并[1，2-a]嘧啶类化合物。反应均在无催化剂条件下以水作反应溶剂进行，实验结果表明采用微波辐射优于常规方法，三组分摩尔比为: n(2-氨基苯并咪唑)/n(丙二腈)/n(取代苯甲醛) = 1：1.1：1，辐射功率为400 W，时间为6～8 min时，1,4-二氢苯并咪唑并[1，2-a]嘧啶的收率在85%以上，反应速率比常规加热条件下提高70倍。通过该系列化合物荧光发射光谱的研究证实具有明显的荧光性质，其荧光发射峰位于480～550 nm。

关键词: 微波辐射, 二氢苯并咪唑并[1,2-a]嘧啶, 水, 荧光

Abstract:

A series of Pyrimido[1,2-a]benzimidazoles derivatives were synthesized by the reaction of 2-aminobenzimidazole with an aldehyde in the presence of malononitrile via Microwave Irradiation or classical heating conditions in water without using any catalyst. The results showed the optimal conditions of the reaction: the mole ratio of three component (malononitrile/aldehyde/2-aminobenzimidazole) is 1.1 and the microwave irradia- tiontime was 6 min with the power of 400 W, The total yield of 1,4-dihydro -pyrimido-[1,2-a]benzimidazole was above 85%. The reaction rate was increased by 70 times against ordinary heating. Their optical characteristics are tested by the fluorescence spectrum. The peaks at the range from 480nm to 550nm are observed in their fluorescence emission spectrum.

Key words: Microwave Irradiation, dihydropyrimido[1,2-a]benzimidazole, water, fluorescence

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