壳聚糖/聚乙烯醇/三聚磷酸钠三元复合微球的制备及表征

摘要/Abstract

摘要：

由壳聚糖（ＣＳ）、聚乙烯醇（ＰＶＡ）和三聚磷酸钠（ＴＰＰ）制备了壳聚糖／聚乙烯醇／三聚磷酸钠三元复
合微球，探讨了体系中壳聚糖含量对复合微球的影响，以及离子种类及浓度和ｐＨ值对复合微球溶胀度的影
响。采用ＸＲＤ、ＦＴＩＲ和ＳＥＭ等测试技术对微球的组分、结构和形貌进行了表征。结果表明，ＣＳ和ＰＶＡ具有良好的相容性，随着ＣＳ含量的增加，ＰＶＡ的结晶性逐渐降低，复合微球的粒径约为４００～９５０ μｍ，表面较为粗糙；随着ＣＳ添加量的增加，凝胶平衡溶胀度先增大再减小，ＣＳ／ＰＶＡ／ＴＰＰ复合微球在ｐＨ值为３～8的溶胀度最大，且在同一种溶液中，随着离子浓度的增加，其溶胀度明显降低；复合微球具有溶胀收缩可逆性，显示ＣＳ／ＰＶＡ／ＴＰＰ复合微球是ｐＨ／离子敏感型凝胶，可为药物缓释系统提供实验和理论依据。

关键词: 壳聚糖，聚乙烯醇，相容性，平衡溶胀度，药物载体

Abstract:

Chitosan/polyvinyl alcohol/sodium tripolyphosphate complex microparticles were prepared from chitosan, polyvinyl alcohol and sodium tripolyphosphate. The effects of CS content on complex microparticles and different ions, pH on the degree of equilibrium swelling were investigated. The component, structure and morphology of complex microparticles were characterized by means of X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM). The results indicate that the chitosan-polyvinyl alcohol is a compatible system; the crystallization of PVA declines with the increase of CS content; the particle size is about 400-950 μm with rough surfaces. The equilibrium swelling tests show that with the increasing of CS content, the equilibrium swelling ratio increases firstly, then decreases; the equilibrium swelling ratio of CS/PVA/TPP complex microparticles in pH=3-8 solution is the best and in the same solution, that of microparticles decreases with the ion content increases.The microparticles have swelling-shrinking reversibility, implying that CS/PVA/TPP complex microparticles are pH/ion-sensitive and could provide experimental and theoretical basis for drug delivery system.

Key words: chitosan,polyvinyl alcohol,compatibility,degree of equilibrium swelling,drug carriers

中图分类号:

O636.1

黄琼瑜,张明霞,刘芳,肖秀峰,刘榕芳. 壳聚糖/聚乙烯醇/三聚磷酸钠三元复合微球的制备及表征[J]. 应用化学, 2010, 27(01): 21-26.

HUANG Qiong-Yu, ZHANG Ming-Xia, LIU Fang, XIAO Xiu-Feng, LIU Rong-Fang*. Preparation and Performance of Chitosan-Polyvinyl Alcohol-sodium Tripolyphosphate Complex Microparticles[J]. Chinese Journal of Applied Chemistry, 2010, 27(01): 21-26.

参考文献

[1]Qian Jun-min(钱军民),Zhang Xing(张兴), Lǚ Fei(吕飞), Li Xuxiang(李旭祥), Adv Fine Petrochem (精细石油化工进展) [J], 2002, 3(3): 22

[2]Wang Fang(王芳), Li Dong(李东), Yu Hua-yun(于华芸), Chinese Journal of Practice Medicine(中华医学实践杂志) [J], 2004,12: (3):1082

[3]Yao Kang-de(姚康德), Yi Yu-ji(尹玉姬), Biomaterials Related to Tissue Engineering(组织工程相关生物材料) [M]. Beijing(北京): Chemical Industry Press(化学工业出版社),2003:61

[4]Ma Guang-hui(马光辉), Su Zhi-guo(苏志国), Macromolecule Microspheres Material(高分子微球材料) [M]. Beijing(北京): Chemical Industry Press(化学工业出版社), 2005: 244

[5]Bjork E, Edman P, Int J Pharm [J], 1990,62:187

[6]Mou Yuan-hua(牟元华), Li Yu-bao(李玉宝), Zhang Xiang(张翔), Lǚ Guo-yu(吕国玉), Zuo Yi(左奕), Xu Feng-lan(许凤兰), J Functional mater(功能材料) [J], 2005,36(10):1578

[7]Wang Ding-guo(王定国), Zheng Hua(郑华), Hu Ying-jia(胡颖嘉), Qiu Shu-ming(邱书明), Beijing Biomedical Engineering (北京生物医学工程) [J], l996, 15(3): l65

[8]Huang Xun-ming(黄循明), Wang Min(王敏), Huang Liang-min(黄良敏), Chinese Journal of Marine Drugs (中国海洋药物) [J], 2003, 3:25

[9]Zheng A P, Wang J C, Lu W L, Zhang X, Zhang H, Wang X Q, Zhang Q, J Nanosci Nanotechnol [J], 2006, 6(9-10):2936

[10]Downs E C, Robertson N E, Riss T L, Plunkett M L, J Cell Physiol. [J], 1992,152:422

[11]Denkbas E B, Seyyal M. Piskin E, J Membrane Science [J], 2000,172(1-2):33

[12]Sarkhel D, Roy D, Bandyopadhyay M, Bhattacharya P, Sep Purif Tech[J], 2003,30:89

[13]Pandey L K, Saxena C, Dubey V, J Membrane Science[J], 2003,227(1-2):173

[14]Yu Ruo-bing(余若冰), You Hua-yan(游华燕), Xu Xiong-li(徐雄立), Li Hua-xing(郦华兴), Modern Plastics Processing and Applications (现代塑料加工与应用) [J], 2000,13(2):16

[15]Sannan T, Kurta K. Ogura K, Inakura Y, Polymer [J], 1978,19: 458

[16]Mima S, Miya M, IwamotoR, Yoshikawa S, Journal of Applied Polymer Science [J], 1983,28:1909

[17]Liu Ming-zhu(柳明珠), Qian Ren-yuan(钱人元), Acta Polymerica Sinica (高分子学报) [J], 1996(2):234

[18]Wu Guo-jie(吴国杰), Cui Ying-de(崔英德), J Chem Ind Eng(China) (化工学报) [J], 2006,57(9):2223