中华医学超声杂志

应用化学 ›› 1998, Vol. 0 ›› Issue (3): 91-93.

• 研究论文 • 上一篇    下一篇

聚(ε-己内酯)/聚(d,l-丙交酯)共混物膜在酶促降解过程中的形态变化

张杰1, 甘志华2, 梁奇志2, 景遐斌2   

  1. 1. 吉林工业大学理学院应用化学系 长春;
    2. 中国科学院长春应用化学研究所 长春130022
  • 收稿日期:1997-10-30 修回日期:1998-03-31 出版日期:1998-06-10 发布日期:1998-06-10
  • 基金资助:
    中国科学院高分子物理开放实验室基金

The Morphology of Poly(ε-caprolactone)/Poly(d,l-lactide) Blends Film in the Course of Enzymatic Degradation

Zhang Jie1, Gan Zhihua2, Liang Qizhi2, Jing Xiabin2   

  1. 1. Department of Applied Chemistry, Jilin University of Technology, Changchun;
    2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022
  • Received:1997-10-30 Revised:1998-03-31 Published:1998-06-10 Online:1998-06-10

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摘要： 生物降解高分子材料无论在医学领域还是在环境保护方面,都有巨大的应用价值.它在 医学领域上主要用于缝合线,骨固定[1,2],药物释放载体[3].针对实际应用的需要,要求生物降 解高分子化合物具有适宜的生物降解速率和良好的力学性能.因此,必须阐明聚合物结构与 性能之间的关系,特别是影响聚合物降解速率的化学结构和物理形态,才能针对实际需要合成 出化学结构明确、综合性能优越的生物降解高分子.

关键词: 聚己酸内酯-聚丙交酯共混物, 酶促降解, 形态

Abstract: The degradation behavior of poly(ε-caprolactone)(PCL)/poly(d,l-lactide)(PLA) blend films prepared by solution casting method have been studied in the phosphate buffer solution containing pseudomonas lipase(PS). PCL was found to be degraded and PLA remained as before. The SEM results indicated that the change both in the surface and inside of the film was owing to the degradation of PCL component in the blends.

Key words: polycaprolatone-polylactide blend, enzymatic degradation, morphology

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