中华医学超声杂志

应用化学 ›› 1995, Vol. 0 ›› Issue (2): 101-103.

• 研究论文 • 上一篇    下一篇

NaBH3CN-ZnCl2体系对含氧二茂铁衍生物的选择性还原

林欣欣1, W E Lindsell2   

  1. 1. 中国科学院广州化学研究所, 广州 510650;
    2. Deparrment of Chemistry, Heriot-Watt University, United Kingdom
  • 收稿日期:1994-07-24 修回日期:1994-12-02 出版日期:1995-04-10 发布日期:1995-04-10

Selective Reduction of Oxygen-Containing Ferrocene Derivatives with NaBH3CN-ZnCl2

Lin Xinxin1, W E Lindsell2   

  1. 1. Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou 510650;
    2. Deparrment of Chemistry, Heriot-Watt University, United Kingdom
  • Received:1994-07-24 Revised:1994-12-02 Published:1995-04-10 Online:1995-04-10

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摘要： 含氧二茂铁衍生物的选择性还原在二茂铁衍生物制备上是一个很重要的反应.当衍生物中同时存在酞基和淡基时,用经典的Clemmenson还原,在高压釜中进行把催化加氢氢化铿铝还原,三抓化铁一氢化理铝体系都不能选择性地将二茂铁上的酞基还原为亚甲基而不使淡基受影响.我们发现NaBH3CN-ZnCl2:体系具备这种选择性.并具有试剂易处理,反应易操作等优点.

关键词: 氰基硼氢化钠, 二氯化锌, 二茂铁衍生物, 选择性还原

Abstract: NaBH3CN-ZnCl2 was applied for the selective reduction deoxygenation of hydroxyland carbonyl groups in ferrocene derivatives under mild condition without affecting on thecarboxy groups.The molar ratio of B/Fe and Zn/Fe,as well as the solvents showed important influences on the deoxygenation.The possible intermediates were suggested.

Key words: sodium cyanoborohydrate, zink chloride, ferrocene derivative, selective reduction

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