中华医学超声杂志

应用化学 ›› 1994, Vol. 0 ›› Issue (6): 73-76.

• 研究论文 • 上一篇    下一篇

1－羟基－2(1H)－吡啶硫酮及其甲基衍生物与Au(Ⅲ)配合物的合成和性质

宋保林1, 卢祥生1, 牛德仲1, 曹阳1, 路再生1, 李金良1, 汪丽玉2   

  1. 1. 徐州师范学院化学系 徐州 221009;
    2. 徐州医学院附属医院 徐州
  • 收稿日期:1994-03-09 修回日期:1994-06-21 出版日期:1994-12-10 发布日期:1994-12-10
  • 基金资助:
    江苏省自然科学基金资助课题

Synthesis and Properties of Coordination Compounds of Au(Ⅲ) with 1-Hydroxy-2-(1H)-Pyridinethione and Its Methyl Derivatives

Song Baolin1, Lu Xiangsheng1, Niu Dezhong1, Cao Yang1, Lu Zaisheng1, Li Jinliang1, Wang Liyu2   

  1. 1. Department of Chemistry, Xuzhou Teachers'COllege, Xuzhou 221009;
    2. The Affiliatied Hospital of Xuzhou Medical CoIIege, Xuzhou
  • Received:1994-03-09 Revised:1994-06-21 Published:1994-12-10 Online:1994-12-10

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摘要： 合成了1-羟基-2-(1H)-吡啶硫酮(HPT)及其甲基衍生物的[AuL2]OH型配合物(L=PT-,3-CH3-PT-和4-CH3-PT-).用元素分析,紫外光谱,红外光谱,1H NMR谱,摩尔电导,TG-DTA-DTG进行了表征,用循环伏安法研究其氧化还原性质,含甲基的配合物有较强的抑菌活性。

关键词: Au(Ⅲ)配合物, 羟基吡啶硫酮, 羟基甲基－吡啶硫酮, 抑菌活性

Abstract: Three new-type complexes,[AuL2]OH (HL:1-hydroxy-2-(1H)-pyridine-thione and its 3- and 4-met hyl-derivatives),were prepared. They have been characterized by elemental analysis,UV,IR,1H NMR,molar conductance and TG-DTA-DTG. Their redox properties have been investigated by cyclic voltammetry. The complexes having CH3 substituent in pyridine ring showed a fairly high antibacterial activity.

Key words: gold complex, hydroxy pyridinethione, hydroxy methyl pyridinethione, antibacterial activity

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