含有苯磺酰胺基团1,2,4-三唑和噻二唑类化合物的设计、合成及抑菌活性

doi:10.11944/j.issn.1000-0518.2017.10.170163

摘要/Abstract

摘要：

为了探索高效低毒、环境友好的新型杀菌剂,本文设计合成系列含有苯磺酰胺片段的1,2,4-三唑和噻二唑类化合物。所有目标化合物的结构由核磁共振波谱、质谱和元素分析确认。离体抑菌活性测试结果表明,部分化合物对7种常见植物病原真菌表现出不同的抑制作用,其中化合物10a、10g和10n对水稻恶苗病菌的抑制活性较高为48.6%,接近商品化杀菌剂嘧菌酯(52.9%)。以上结果可能为后续的分子设计提供依据。

关键词: 三唑, 噻二唑, 苯磺酰胺, 抑菌活性

Abstract:

In order to explore efficient, low toxic and eco-friendly fungicides, a series of 1,2,4-triazole and thiadiazole derivatives containing benzenesulfonamide moieties was designed and synthesized. Their chemical structures were confirmed by nuclear magnetic resonance spectroscopy(NMR), mass spectrometry and elemental analysis. Preliminary fungicidal bioassay in vitro was carried out against seven plant pathogenic fungi and the results showed that compounds 10 exhibited moderate fungicidal activities, especially 10a, 10g and 10n demonstrated similar high inhibition rate against Fusarium moniliforme in comparison with commercial Azoxystrobin.

Key words: triazole, thiadiazole, benzenesulfonamide, fungicidal activity

陈明桂, 华学文, 魏巍, 张冬凯, 刘明, 吴长春, 李玉新, 王宝雷, 周莎, 李正名. 含有苯磺酰胺基团1,2,4-三唑和噻二唑类化合物的设计、合成及抑菌活性[J]. 应用化学, 2017, 34(10): 1161-1171.

CHEN Minggui, HUA Xuewen, WEI Wei, ZHANG Dongkai, LIU Ming, WU Changchun, ZHOU Sha, LI Yuxin, WANG Baolei, ZHOU Sha, LI Zhengming. Design, Synthesis and Fungicidal Bioactivity of 1,2,4-Triazoles or Thiadiazoles Containing a Benzenesulfonamide Moiety[J]. Chinese Journal of Applied Chemistry, 2017, 34(10): 1161-1171.

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