中华医学超声杂志

应用化学 ›› 2010, Vol. 27 ›› Issue (02): 246-248.DOI: 10.3724/SP.J.1095.2010.90063

• 研究简报 • 上一篇    

加压毛细管电色谱法分离1-甲基-3-苯基丙胺对映体

李英杰*,孙鹏,高立娣   

  1. (齐齐哈尔大学化学与化学工程学院 齐齐哈尔 161006)
  • 收稿日期:2009-01-20 修回日期:2009-04-02 出版日期:2010-02-10 发布日期:2010-02-10
  • 通讯作者: 李英杰，男，教授; E-mail:Liyingjie310@163.com; 研究方向：毛细管电泳、电色谱分析

Enantiomeric separation of 1-dimethyl-3-phenylpropylamine by Pressurized Capillary electrochromatography

LI Ying-Jie*, SUN Feng, GAO Li-Di   

  1. (Qiqihar University of Chemistry,Chemical Engineering Institute,Qiqihar 161006)
  • Received:2009-01-20 Revised:2009-04-02 Published:2010-02-10 Online:2010-02-10

PDF

1217

被引次数

10

摘要：

运用毛细管电色谱（pCEC）模式，以羟丙基-β-环糊精（HP-β-CD）作为手性选择剂，对1-甲基-3-苯基丙胺对映体进行手性分离。1-甲基-3-苯基丙胺对映体在最佳的条件下如：手性选择剂浓度10 g/L、流动相配比：V(乙腈)∶V(磷酸盐体系)=60∶40溶液(5 mmol/L）、背景电解质pH=7.6、柱温16 ℃和分离电压10 kV达到了基线分离,该方法重现性好、简便、快捷。

关键词: 加压毛细管电色谱，甲基苯基丙胺，对映体拆分，羟丙基-β-环糊精

Abstract:

1-Dimethyl-3-phenylpropylamine enantiomer was separated with hydroxypropyl-β-cyclodextrin（HP-β-CD） as chiral selector by means of pressurized capillary electrochromatography(pCEC). The optimal experimental conditions are HP-β-CD concentration 10 g/L, background buffer pH=7.6, capillary temperature 16 ℃, voltage 10 kV, and the mobile phase consisted of a solution of acetonitrile and phosphate at a volume ratio of V(CH3CN)∶V(NaH2PO4-Na2HPO4)=60∶40. The method is simple, rapid and the reproducibility is good.

Key words: pressurized capillary electrochromatography(pCEC),dimethylphenylpropylamine,enantiomer separation,hydroxypropyl-β-cyclodextrin

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