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金纳米颗粒等离子体共振吸收光谱检测头孢唑啉

李靖云,王燚,许佳丽,李原芳*   

  1. (发光与实时分析教育部重点实验室,西南大学化学化工学院 重庆 400715)
  • 收稿日期:2011-05-30 修回日期:2011-08-01 出版日期:2012-04-10 发布日期:2012-04-10
  • 通讯作者: 李原芳，教授; Tel:023-68254659; Fax:023-68367257; E-mail:lyf@swu.edu.cn; 研究方向：化学与生物药物分析
  • 基金资助:
    国家自然科学基金(NSFC,20775061)和西南大学大型仪器设备开放基金资助项目

Detection of Cefazolin Based on the Plasma Resonance Absorption of Gold Nanoparticles

LI Jingyun, WANG Yi, XU Jiali, LI Yuanfang*   

  1. (Education Ministry Key Laboratory on Luminescence and Real-Time Analysis,College of
    Chemistry and Chemical Engineering,Southwest University,Chongqing 400715)
  • Received:2011-05-30 Revised:2011-08-01 Published:2012-04-10 Online:2012-04-10

PDF

1726

被引次数

6 | 3

摘要： 根据金纳米粒子等离子体共振吸收引起的溶液颜色变化，建立了一种快速、简便检测头孢唑啉的色度分析方法。 方法线性范围为0.1~5.0 μmol/L，检测限为14 nmol/L。 将该方法用于头孢唑啉钠粉针剂的分析，回收率在97.4%~100.2%之间，相对标准偏差小于6.1%。

关键词: 金纳米颗粒, 头孢唑啉, 氯化钠, 等离子体共振吸收, 色度法

Abstract: The cefazolin can be detected according to the change of solution color resulting from the plasmonic resonance absorption of AuNPs. The absorbance ratio at 520/660 nm of AuNPs is proportional to the concentration of cefazolin in the range of 0.1~5.0 μmol/L with the detection limit of 14 nmol/L. This method could be extended to the determination of cefazolin sodium powder injection, the recovery of cefazolin was in the range of 97.4%~100.2% while the relative standard deviation was less than 6.1%.

Key words: Gold nanoparticles, Cefazolin, Sodium chloride, Plasma resonance absorption, Colorimetric determination

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