Polyurethane Dressing Based on Antibacterial Chitosan/Carboxymethyl Cellulose Composite Drug Coating

doi:10.19894/j.issn.1000-0518.220164

Chinese Journal of Applied Chemistry ›› 2023, Vol. 40 ›› Issue (2): 252-260.DOI: 10.19894/j.issn.1000-0518.220164

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Polyurethane Dressing Based on Antibacterial Chitosan/Carboxymethyl Cellulose Composite Drug Coating

Yu-Zhu CHEN, Si-Si LIU, Meng-Meng ZHANG, Xiang-De LIN(), Dong-Dong ZENG()

School of Medical Devices，Shanghai University of Medicine & Health Science，Shanghai 201318，China

Received:2022-05-01 Accepted:2022-08-30 Published:2023-02-01 Online:2023-02-27
Contact: Xiang-De LIN,Dong-Dong ZENG
About author:zengdd@sumhs.edu.cn；
linxd@sumhs.edu.cn
Supported by:
the Natural Science Foundation of Shanghai(22008151);the National Natural Science Foundation of China(19ZR1474300);the High-level Local University Construction Project of shanghai University of Medicine & Health Sciences(E1-2602-21-201006-1)

Abstract

Abstract:

Using antibacterial chitosan and carboxymethyl cellulose as the main coating materials， the polyurethane dressing based on antibacterial chitosan/carboxymethyl cellulose composite drug coating is constructed by using antibacterial matrine as the functional drug through the layer-by-layer self-assembly membrane technology. Furthermore， the internal structure of the polymer is changed by intermolecular chemical cross-linking to improve the mechanical stability of the coating. Composite drug coatings are successfully prepared on silicon wafers and polyurethane dressings， respectively. The drug loading and release properties of crosslinked （CHI/CMC）₂₅ coating， blank polyurethane substrate and crosslinked （CHI/CMC）₁₀ coating modified polyurethane substrate are also analyzed under simulated physiological conditions for matrine with the drug loading of 27.8， 285.2 and 330.0 μg/cm². Compared with the crosslinked （CHI/CMC）₂₅ coating and the blank polyurethane substrate， the drug loading capacity of the polyurethane substrate （CHI/CMC）₁₀ crosslinked coating is improved by 10.9 times and 20%， respectively. The polyurethane substrate not only has excellent drug loading capacity， but also has the effect of delaying drug release rate. The crosslinked （CHI/CMC）₁₀ coating can enhance the mechanical properties of the substrate. Compared with the original poly（ethylene terephthalateco-1，4-cylclohexylen-edimethylene terephthalate （PETG） sheet， the fracture time and standard strain of the PETG sheet-crosslinked （CHI/CMC）₁₀ coating are increased by 25.1%. Bacterial inhibition experiments show that the antibacterial effect of the compound drug coating is enhanced by 1-fold compared with the single drug group due to the synergistic antibacterial effect of chitosan and matrine. The compound drug coating shows significant growth inhibition against Staphylococcus aureus and Escherichia coli， with growth inhibition rates of 35.7% and 53.8%， respectively.

Key words: Polyurethane dressing, Chitosan/carboxymethyl cellulose, Layer-by-layer self-assembly, Composite drug coating, Antibacterial properties

CLC Number:

O636

Yu-Zhu CHEN, Si-Si LIU, Meng-Meng ZHANG, Xiang-De LIN, Dong-Dong ZENG. Polyurethane Dressing Based on Antibacterial Chitosan/Carboxymethyl Cellulose Composite Drug Coating[J]. Chinese Journal of Applied Chemistry, 2023, 40(2): 252-260.

Figures/Tables 8

Fig.1 Schematic diagram of polyurethane dressing based on chitosan and carboxymethyl cellulose compound drug coating

Fig.2 （A） UV-Vis full-spectrum absorbance value of CHI/CMC coating and （B） UV absorption peak of CHI/CMC coating

Fig.3 FT-IR spectra of crosslinked （CHI/CMC）25 coating （a），（CHI/CMC）25 coating （b）， CMC （c） and CHI （d）

Fig.4 SEM images of （A）（CHI/CMC）25 coating，（B） Crosslinked （CHI/CMC）25 coating，（C） Polyurethane substrate （CHI/CMC）10 coating and （D） Polyurethane substrate crosslinked （CHI/CMC）10 coating

Fig.5 Static droplet contact angle of （A）（CHI/CMC）25 coating and （B） cross-linked （CHI/CMC）25 coating

Table 1 Mechanical properties of chemical crosslinked coatings

	Breaking time/min	Standard strain/mm	Elongation after fracture/%	Maximum failure load/N	Tensile strength/MPa
PETG	87.3	130.9	3.3	233.1	45.8
PETG-（CHI/CMC）₁₀	109.2	163.7	3.8	240.5	48.1

Fig.6 （A） Cumulative drug release profiles；（B） Percentage of cumulative drug release

Fig.7 Inhibition of E.coli and S.aureus by Matrine loaded cross-linking （CHI/CMC）25 coating， cross-linking （CHI/CMC）25 coating and Matrine

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Polyurethane Dressing Based on Antibacterial Chitosan/Carboxymethyl Cellulose Composite Drug Coating

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