Preparation and Properties Characterization of Hydrophilic Polysiloxane and Polyvinyl Alcohol Composite as Skin Barrier Material

doi:10.19894/j.issn.1000-0518.210500

Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (8): 1224-1236.DOI: 10.19894/j.issn.1000-0518.210500

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Preparation and Properties Characterization of Hydrophilic Polysiloxane and Polyvinyl Alcohol Composite as Skin Barrier Material

Bing-Gang CHEN¹^,³, San-Rong LIU¹, Zi-Jiang JIANG²(), Xi-Fei YU¹^,³()

^1.Laboratory of Polymer Composites Engineering，Changchun Institute of Applied Chemistry，Chinese Academy of Science，Changchun 130022，China
^2.National Analytical Research Center of Electrochemistry and Spectroscopy，Changchun Institute of Applied Chemistry，Chinese Academy of Science，Changchun 130022，China
^3.University of Science and Technology of China，Hefei 230026，China

Received:2021-10-15 Accepted:2022-01-20 Published:2022-08-01 Online:2022-08-04
Contact: Xi-Fei YU
About author:xfyu@ciac.ac.cn
Supported by:
the National Natural Science Foundation of China Project(21674109)

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Abstract

Abstract:

As the outermost organ of human body， skin is easily injured. Therefore， it is more important to construct protected barrier material for skin. Herein， based on the performance requirement of skin barrier material， we construct a multifunctional skin barrier material PSI-PVA by combining hydrophilically modified polysiloxane （PSI） and polyvinyl alcohol （PVA） through ionic crosslinking. The test results indicate that PSI-PVA exhibits good stretchability in dry and wet and has compatible mechanical properties like skin. PSI-PVA is hydrophilic and the swelling ratio is up to 149% with the PVA content of 20%， and water can volatilize rapidly at room temperature， which makes PSI-PVA good breathability. PSI-PVA has good cleaning performance and can be easily cleaned from skin with water. In addition， PSI-PVA covalently linked with UV-absorbing group of hydroxybenzophenone can effectively decrease UV transmittance. The in vitro experiment indicates that NIH 3T3 cells have high survival rate （71%） irradiated by UVB （311 nm） with the protection of the PSI-PVA film. Furthermore， PSI-PVA also exhibits good biocompatibility through cell viability assay. The skin barrier material PSI-PVA constructed with composite of polysiloxane and polyvinyl alcohol can meet properties requirements and has good application prospects in fields of skin protection and injury repair.

Key words: Polysiloxane, Hydrophilic modification, Polyvinyl alcohol, Ionic crosslinking, Skin barrier material

CLC Number:

O633.1

Bing-Gang CHEN, San-Rong LIU, Zi-Jiang JIANG, Xi-Fei YU. Preparation and Properties Characterization of Hydrophilic Polysiloxane and Polyvinyl Alcohol Composite as Skin Barrier Material[J]. Chinese Journal of Applied Chemistry, 2022, 39(8): 1224-1236.

Figures/Tables 9

Fig.1 Schematic illustration of preparation and properties of skin barrier materials （SBM） based on polysiloxane and PVA composite

Fig.2 The 1H NMR （A） and FT-IR （B） spectra of PDMS-PVMS， PDMS-PVMS-COOH and PDMS-PVMS-COO-Na+

Fig.3 Mechanical properties： tensile curve （A） and Young's Modulus （B） of PSI-PVA film with different modified ratio of —COO-Na+ （PVA mass fraction was 9.10%， concentration of Ca2+ was 0.5 mol/L）； tensile curve （C） and Young's Modulus （D） of PSI-PVA film with different mass fraction of PVA （—COO-Na+ mole fraction was 10%， concentration of Ca2+ was 0.5 mol/L）； tensile curve （E） and Young′s Modulus （F） of PSI-PVA film with different content of water （—COO-Na+ mole fraction was 10%， PVA mass fraction was 9.10% and concentration of Ca2+ was 0.5 mol/L）；（G） Tensile curve of PSI-PVA film with different concentration of Ca2+ （—COO-Na+ mole fraction was 10%， PVA mass fraction was 9.10% ）；（H） Tensile curve of PSI-PVA film with or without Ca2+ crosslinking （—COO-Na+ mole fraction was 10%， PVA mass fraction was 9.10% and water content was 10%）

Fig.4 The swelling ratio of PSI-PVA film in water and artificial sweat with different PVA mass fraction （A）（concentration of Ca2+ was 0.5 mol/L）， with different concentration of Ca2+ （B）（PVA mass fraction was 20%）；（C） The photograph of PVA film in water （after dyeing， scale bar was 1 cm）； The variation of water content with time of PSI-PVA film absorbing water （D） and artificial sweat （E） in room temperature （room temperature was 18 ℃ and relative humidity was 30%， concentration of Ca2+ was 0.5 mol/L）；（F） The WVTR of PSI-PVA film with different mass fraction of PVA （concentration of Ca2+ was 0.5 mol/L）

Fig.5 Cleaning properties： the cleaning situation of PSI-PVA film with different mass fraction of PVA after Ca2+ crosslinking （A）， with PVA mass fraction of 20% after non-crosslinking （B）（the concentration of Ca2+ was 0.5 mol/L， scale bar was 1 cm）

Fig.6 The SEM morphology （A） and water contact angle （B） of PSI-PVA film with different mass fraction of PVA （the concentration of Ca2+ was 0.5 mol/L， scale bar was 50 μm）

Fig 7 （A） The UV absorbance of PSI in THF solution （0.5 mg/mL） with different mass fraction of UV-0；（B） The UV transmittance of PSI-PVA and PSI（UV）-PVA film （1.2 mg/cm2）； the UV transmittance of PSI-PVA film （C） and PSI（UV）-PVA film （D） with different coating amount （PVA mass fraction was 9.10%， the concentration of Ca2+ was 0.5 mol/L）

Fig.8 Anti-UV properties：（A） the schematic illustration of UV-shielding properties in vitro； the live/dead cell ratio （B） and live/dead stain images （C） of NIH 3T3 cell in different protected situations after UV irradiation （PVA mass fraction was 9.10%， the concentration of Ca2+ was 0.5 mol/L， scale bar was 100 μm）

Fig 9 Biocompatibility：（A） The cell viability of NIH 3T3 incubated for 24 h with different concentrations of PSI-PVA and PSI（UV）-PVA solutions； The live/dead stain images of NIH 3T3 cell incubated on different sample films for 24 h：（B） Control；（C） PSI-PVA film；（D） PSI（UV）-PVA film （PVA mass fraction was 9.10%， the concentration of Ca2+ was 0.5 mol/L， scale bar was 50 μm）

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Preparation and Properties Characterization of Hydrophilic Polysiloxane and Polyvinyl Alcohol Composite as Skin Barrier Material

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