Chinese Journal of Applied Chemistry ›› 2022, Vol. 39 ›› Issue (1): 18-34.DOI: 10.19894/j.issn.1000-0518.210446

• Review • Previous Articles     Next Articles

Research Progress on Bioinspired Organs⁃on⁃Chips

SUN Ling-Yu,GUO Jia-Hui,WANG Yu,XU Dong-Yu,ZHAO Yuan-Jin()   

  1. State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China
  • Received:2021-09-01 Accepted:2021-10-08 Published:2022-01-01 Online:2022-01-10
  • Contact: Yuan-Jin ZHAO
  • About
  • Supported by:
    the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060);Shenzhen Fundamental Research Program(JCYJ20190813152616459)


In the long process of evolution, nature has created numerous natural materials with excellent properties, which provides inspiration for the design and fabrication of artificial materials, as well as the development of related disciplines. With the advances in material science and manufacturing technology, bio-inspired materials are attracting extensive research and thus experiencing a rapid development. Based on elaborate morphology and component design, bioinspired materials have acquired diverse functions such as self-adaptation, self-healing, self-cleaning, fog collection, etc. Up to date, the bioinspired materials with extraordinary performances have demonstrated practical values in medicine, aerospace, biomedical field, daily life, and so on. In particular, the bioinspired materials could serve as biological scaffolds for cell culture and be further integrated into microfluidic chips to construct organ-on-chips systems. Compared with traditional cell experiments and animal models, the organ-on-chips platform is more appropriate for drug screening and disease model research, which could be attributed to the advantages of miniaturization, low consumption and more physiological-like environment. In this review, after introducing the fabrication method, we present the specific functions or features of the derived bioinspired materials. The focus of this review is concentrated on the integration of bioinspired materials into organ-on-chips and their applications. Finally, the challenges and opportunities of current organ-on-chips are also prospected.

Key words: Bioinspired, Cell culture, Organ-on-a-chip, Microfluidics, Drug screening

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