Dihydroisocoumarin Compounds from Endophytic Fungi of Rhizophora apiculata and Its Antibacterial Activity

doi:10.11944/j.issn.1000-0518.2018.06.170281

Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (6): 708-713.DOI: 10.11944/j.issn.1000-0518.2018.06.170281

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Dihydroisocoumarin Compounds from Endophytic Fungi of Rhizophora apiculata and Its Antibacterial Activity

LING Huiping^a,CHEN Xiaoqing^a,XIE Shengnan^a,CHEN Yuejian^a,SHE Zhigang^b,LIN Yongcheng^b,TAO Yiwen^a^*()

^aSchool of Pharmaceutical Sciences,Guangzhou Medical University,Guangzhou 511436,China
^bSchool of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China

Received:2017-08-10 Accepted:2017-11-29 Published:2018-06-01 Online:2018-05-28
Contact: TAO Yiwen
Supported by:
Supported by the Natural Science Program of Guangdong Province(No.2016A030313588), the Education Bureau Project of Guangzhou City(No.1201610155), the Projects of Guangdong Oceanic and Fishery Administration in 2017(No.A201701C07), the Open-Laboratory Project of Guangzhou Medical University in 2018

Abstract

Abstract:

In order to study the secondary metabolites of dihydroisocoumarin compounds from mangrove endophytic fungi Fusarium sp. F67 and B42, the metabolites of strains F67 and B42 were isolated and purified by chromatographic techniques, and their structures were determined as follows: 3,6,8-trihydroxy-3,4,5,7-tetramethyl-3,4-dihydroisocoumarin(sclerotinin A)(1), dihydrocitrinone(2), 5-methylmellein(3), 5-carboxymellein(4), 4-hydroxymellein(5) and mellein(6). Antibacterial activities of compounds 1~4 in 1.0 g/L show that the inhibitory zone against the tested strains ranges from 5.1 to 11.0 mm. Among them, compound 4 has the strongest antibacterial activities and the broadest bacteriostatic spectra. These results provide supplement to the research and development of new antibacterial drug.

Key words: Rhizophora apiculata, endophytic fungi, dihydroisocoumarins, antibacterial activity

LING Huiping,CHEN Xiaoqing,XIE Shengnan,CHEN Yuejian,SHE Zhigang,LIN Yongcheng,TAO Yiwen. Dihydroisocoumarin Compounds from Endophytic Fungi of Rhizophora apiculata and Its Antibacterial Activity[J]. Chinese Journal of Applied Chemistry, 2018, 35(6): 708-713.

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Dihydroisocoumarin Compounds from Endophytic Fungi of Rhizophora apiculata and Its Antibacterial Activity

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