Inhibitory Effect of Vanadium-Substituted Dawson Type Phosphomolybdic Acid on Tyrosinase

doi:10.11944/j.issn.1000-0518.2018.04.170130

Chinese Journal of Applied Chemistry ›› 2018, Vol. 35 ›› Issue (4): 436-441.DOI: 10.11944/j.issn.1000-0518.2018.04.170130

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Inhibitory Effect of Vanadium-Substituted Dawson Type Phosphomolybdic Acid on Tyrosinase

Lili LI,Yangyang DENG,Lefang XIE,Li WANG()

College of Food and Biological Engineering,Jimei University,Xiamen,Fujian 361021,China

Received:2017-04-24 Accepted:2017-08-22 Published:2018-03-30 Online:2018-04-02
Contact: Li WANG
Supported by:
Supported by the National Natural Science Foundation of China(No.21371072)

Abstract

Abstract:

In this paper, the inhibitory effects of five Dawson type phosphomolybdic acids, e.g., H₇[P₂Mo₁₇VO₆₂], H₈[P₂Mo₁₆V₂O₆₂], H₉[P₂Mo₁₅V₃O₆₂], H₈[P₂Mo₁₄V₄O₆₂H₂] and H₉[P₂Mo₁₃V₅O₆₂H₂](abbreviated to P₂Mo₁₇V, P₂Mo₁₆V₂, P₂Mo₁₅V₃, P₂Mo₁₄V₄ and P₂Mo₁₃V₅, respectively), on the diphenolase activity of mushroom tyrosinase were investigated by enzyme kinetics methods. The results show that P₂Mo₁₇V, P₂Mo₁₆V₂ and P₂Mo₁₅V₃ have significant inhibitory effects on tyrosinase, and the half maximal inhibitory concentration(IC₅₀) values of them are 0.409, 0.386 and 0.386 mmol/L, respectively. They are reversible and competitive inhibitors, and the inhibition constants are 0.234, 0.391 and 0.249 mmol/L, respectively. P₂Mo₁₃V₅ can activate diphenolase activity of tyrosinase while P₂Mo₁₄V₄ in 0~1.0 mmol/L has no obvious effects on the diphenolase activity of tyrosinase.

Key words: tyrosinase, inhibitor, phosphomolybdic acid, diphenolase activity

Lili LI, Yangyang DENG, Lefang XIE, Li WANG. Inhibitory Effect of Vanadium-Substituted Dawson Type Phosphomolybdic Acid on Tyrosinase[J]. Chinese Journal of Applied Chemistry, 2018, 35(4): 436-441.

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Inhibitory Effect of Vanadium-Substituted Dawson Type Phosphomolybdic Acid on Tyrosinase

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