Research Progress of Fluorescent Zinc Probes

doi:10.11944/j.issn.1000-0518.2017.12.170302

Chinese Journal of Applied Chemistry ›› 2017, Vol. 34 ›› Issue (12): 1355-1369.DOI: 10.11944/j.issn.1000-0518.2017.12.170302

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Research Progress of Fluorescent Zinc Probes

BU Lulu,WANG Qing,XIE Yongshu()

Shanghai Key Laboratory of Functional Materials Chemistry,East China University of Science and Technology,Shanghai 200237,China

Received:2017-08-29 Accepted:2017-10-09 Published:2017-12-04 Online:2017-12-04
Contact: XIE Yongshu
Supported by:
Supported by the National Natural Science Fundation of China(No.21472047, No.21772041, No.21702062), the Shanghai Oriental Scholar Distinguished Professor Project(No.GZ2016006), the Central University Basic Research Fellowship(No.WK1616004, No.222201717003, No.222201714013)

Abstract

Abstract:

It is of great importance to selectively detect and effectively monitor zinc ion because of its wide distribution in human cells and vital roles in human metabolism. Fluorescent probes have been extensively applied in zinc sensing because of the advantages of simple-design, easy-operation, high sensitivity and cell imaging capability. Fluorescent zinc probes are generally constructed based on the mechanisms of photo-induced electron transfer, intra-molecular charge transfer, fluorescence resonance energy transfer, aggregation-induced emission and chelation-enhanced fluorescence. Among these mechanisms, zinc probes constructed on chelation-enhanced fluorescence have the advantages of easy design and synthesis because its fluorophore can simultaneously act as the receptor. In this review, fluorescent zinc probes based on the aforementioned mechanisms, especially, chelation-enhanced fluorescence, reported in recent years are briefly summarized.

Key words: zinc ion, fluorescent probes, sensing mechanism, chelation-enhanced fluorescence, cell imaging

BU Lulu,WANG Qing,XIE Yongshu. Research Progress of Fluorescent Zinc Probes[J]. Chinese Journal of Applied Chemistry, 2017, 34(12): 1355-1369.

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Research Progress of Fluorescent Zinc Probes

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