Research of False Positive Phenomenon in Organotin Determination Based on Gastric Juice Migration Model

doi:10.11944/j.issn.1000-0518.2016.10.150453

Chinese Journal of Applied Chemistry ›› 2016, Vol. 33 ›› Issue (10): 1210-1217.DOI: 10.11944/j.issn.1000-0518.2016.10.150453

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Research of False Positive Phenomenon in Organotin Determination Based on Gastric Juice Migration Model

LI Hanke^a,HUANG Li'na^b^*(),YI Lezhou^b,CHEN Yang^b,MA Tongmei^a,PENG Feng^a

^aSchool of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou 510640,China
^bInspection and Quarantine Technology Center,Guangdong Exit-Entry Inspection and Quarantine Bureau,Guangzhou 510623,China

Received:2015-12-18 Accepted:2016-04-12 Published:2016-10-08 Online:2016-10-08
Contact: HUANG Li'na
Supported by:
Supported by the Planned Projects of Guangdong Provincial Department of Science and Technology(No.2013B04042005, No.50324310055), the Technical Project of China National Accreditation Services for Conformity Assessment(No.2014CNAS08)

Abstract

Abstract:

Organotin, a group of high risk hazardous substances, is highly concerned in consuming products testing. False positive of methyltin species is frequently found in routine analysis of migratable organotin compounds in surface coatings of tins or tin plated materials. It was found by GC-MS that 0.56 mg/L triethylmethyltin(TEMT) had been converted from elemental tin by using metal tin powder to simulate inorganic tin content present in actual samples. Three possible assumptions concerning the source of triethylmethyltin were then proposed:1)TEMT derived from reaction of inorganic tin with trace methylating agent contained in derivatization reagent. 2)TEMT derived from decomposition of tetraethyltin(TrET) at sample inlet or inside the column. 3)TEMT derived from methyl-substitution reaction of TrET or residual contamination of sample inlet . Relevant confirmation experiments were then carried out accordingly. It was finally found that triethylmethyltin had been generated from very little amount of methylating agents present in the derivatization reagent-sodium tetraethylborate. Therefore, the content of non-ethyl alkylation agent contained in the derivatization reagent should be specified in related standards to avoid arousing erroneous judgment.

Key words: gastric juice migration model, organotin, false positive, triethylmethyltin

LI Hanke, HUANG Li'na, YI Lezhou, CHEN Yang, MA Tongmei, PENG Feng. Research of False Positive Phenomenon in Organotin Determination Based on Gastric Juice Migration Model[J]. Chinese Journal of Applied Chemistry, 2016, 33(10): 1210-1217.

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Research of False Positive Phenomenon in Organotin Determination Based on Gastric Juice Migration Model

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