Synthesis, Structure and Antitumor Activity of Tri(o-bromobenzyl)tin Dithiotetrahydropyrrolocarbamate

doi:10.3724/SP.J.1095.2014.30212

Chinese Journal of Applied Chemistry

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Synthesis, Structure and Antitumor Activity of Tri(o-bromobenzyl)tin Dithiotetrahydropyrrolocarbamate

ZHANG Fuxing^*, KUANG Daizhi, FENG Yonglan, WANG Jianqiu, YU Jiangxi, JIANG Wujiu, ZHU Xiaoming

(Key Laboratory of Functional Organometallic Materials of Hengyang Normal University,
College of Hunan Province;Department of Chemistry and Material Science,Hengyang Normal University,Hengyang 421008,China)

Received:2013-04-27 Revised:2013-07-13 Published:2014-03-10 Online:2014-03-10
Contact: Zhang
Supported by:
Supported by the Open Fund Project of Key Laboratory in Hunan Universities(No.12K124), Hunan Provincial Natural Science Foundation of China(No.11JJ3021), the Construct Program of the Key Discipline in Hunan Province and the Foundation of Key Laboratory of Functional Organometallic Materials, University of Hunan Province

Abstract

Abstract: Tri(o-bromobenzyl)tin bromide was reacted with 1-pyrrolidinecarbodithioicacid sodium salt to synthesize tri(o-bromobenzyl)tin dithiotetrahydropyrrolocarbamate. The crystal structure of tri(o-bromobenzyl)tin dithiotetrahydropyrrolocarbamate was determined by X-ray diffraction. The compound crystallizes in triclinic space group P1 with cell parameters of a=0.91354(11) nm, b=1.07313(13) nm, c=1.52677(18) nm， α=75.440(6)°， β=89.499(6)°， γ=72.515(7)°， V=1.3781(3) nm3， Z=2， Dc=1.868 g/cm3，μ(MoKα)=54.43 cm-1， F(000)=752， R1=0.0320， wR2=0.0765. The tin atom of the compound has a distorted tetrahedral geometry. The stabilities, some frontier molecular orbital energies and composition characteristics of some frontier molecular orbital of the complex were also investigated. Furthermore, the anticancer activity of the complexes was tested.

Key words: tri(o-bromobenzyl)tin dithiotetrahydropyrrolocarbamate, synthesis, structure, antitumor activity

CLC Number:

O612.4

ZHANG Fuxing*, KUANG Daizhi, FENG Yonglan, WANG Jianqiu, YU Jiangxi, JIANG Wujiu, ZHU Xiaoming. Synthesis, Structure and Antitumor Activity of Tri(o-bromobenzyl)tin Dithiotetrahydropyrrolocarbamate[J]. Chinese Journal of Applied Chemistry, DOI: 10.3724/SP.J.1095.2014.30212.

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Synthesis, Structure and Antitumor Activity of Tri(o-bromobenzyl)tin Dithiotetrahydropyrrolocarbamate

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