Abstract: A series of 2-(1,3,4-thiadiazolylaminomethyl)phenols was synthesized by reducing the C=N double bond of the intermediate Schiff bases prepared from the reaction of 2-amino-5-alkyl(aryl)-1,3,4-thiadiazoles and salicylaldehyde via either fractional step method or one-pot process. The yields of the products obtained from one-pot synthesis were higher and in the range of 56%~80%. The structures of the products were characterized by means of IR, 1H NMR, 13C NMR and MS. The fungicidal activity of the title compounds was evaluated preliminarily, some of which exhibited moderate activity against Alternaria alternata. The inhibitory rate of compound 3i was 76% at the concentration of 25 mg/L, and 70% for compounds 3f, 3h, 3k and 3l.

Key words: thiadiazolylaminomethylphenol, synthesis, fungicidal activity