Chinese Journal of Applied Chemistry ›› 1998, Vol. 0 ›› Issue (5): 18-20.

• Full Papers • Previous Articles     Next Articles

Synthesis and Biological Activity of the Derivatives of 2,4,6-Trioxo-1,3,5,2-triazaphosphorine

Lu Shuiming, Chen Ruyu   

  1. Institute of Elemento Organic Chemistry, Nankai University, Tianjin 300071
  • Received:1998-02-18 Revised:1998-06-17 Published:1998-10-10 Online:1998-10-10

Abstract: A series of the title 2,4,6-trioxo-1,3,5,2-triazaphosphorine derivatives have been synthesized by reaction of N,N-bis(2-chloroethyl)aminophosphoryldiisocyanate with ami nes . The structures of the products were confirmed by 1H NMR, IR MS, 31P NMR and elemental analysis. The preliminary bioassay indicated that some of them had antitumor activity.

Key words: triazaphosphorine, synthesis, biological activity