Improvement in Vitamin K1 Synthesis

Chinese Journal of Applied Chemistry ›› 1998, Vol. 0 ›› Issue (4): 98-100.

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Improvement in Vitamin K₁ Synthesis

Ji Yafei¹, Zhang Yanqiu¹, Shi Junying²

1. Department of Energy Utilization and Chemical Engineering, ChinaUniversity of Mining and Technology, Xuzhou 221008;
2. Research Institute of Fine Chemicals, East China Universityof Science and Technology, Shanghai

Received:1997-10-09 Revised:1997-12-25 Published:1998-08-10 Online:1998-08-10

Abstract

Abstract: The Ruettimnann's method^[5] for vitamin K₁ synthesis has been improved by usingphase transfer catalyst in Diels-Alder condensation and using mixed trans-cis phytyl chlorideinstead of natural phytol as starting material in the synthesis.The vitamin K₁ then obtainedby a retro-Diels-Alder reaction has a cis-trans isomer ratio of 20.35 to 79.65 which meets theChinese pharmacopia standard.Phytyl bromide in this case gave vitamin K₁ with cis-trans ratio of 26.30 to 73.70.

Key words: vitamin K₁, synthesis, phytyl chloride, phytyl bromide

Ji Yafei, Zhang Yanqiu, Shi Junying. Improvement in Vitamin K₁ Synthesis[J]. Chinese Journal of Applied Chemistry, 1998, 0(4): 98-100.

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Improvement in Vitamin K₁ Synthesis

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