Synthesis,Spectra and DNA Intercalation of 2H-4,9-Dimethylfuro[2′,3′:5,6] naphtho [1,2-b] pyron-2-one

Chinese Journal of Applied Chemistry ›› 1996, Vol. 0 ›› Issue (4): 34-37.

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Synthesis,Spectra and DNA Intercalation of 2H-4,9-Dimethylfuro[2′,3′:5,6] naphtho [1,2-b] pyron-2-one

Tao Zhifu¹, Qian Xuhong¹, Tang Jun¹, Chen Fuheng²

1. Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, Shanghai 200237;
2. Department of Applied Chemistry, Beijing Agricultural University, Beijing

Received:1995-10-17 Revised:1995-12-18 Published:1996-08-10 Online:1996-08-10

Abstract

Abstract: The title compound was synthesized by three methods from naphthopyrone. The structures of this compound and its precursors were fully characterized by ¹H NMR, MS, IR and elemental analysis.Its DNA-intercalative activity was investigated in DMSO-Tris HCl system by fluorescence quenching technique and the apparent Scatchard binding constant was estimated. Results showed that it efficiently intercalated into DNA.The spectral properties and DNA-intercalative activity have been compared with those of its analogues.

Key words: naphthopyrones, DNA intercalation activity, synthesis, spectrum

Tao Zhifu, Qian Xuhong, Tang Jun, Chen Fuheng. Synthesis,Spectra and DNA Intercalation of 2H-4,9-Dimethylfuro[2′,3′:5,6] naphtho [1,2-b] pyron-2-one[J]. Chinese Journal of Applied Chemistry, 1996, 0(4): 34-37.

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Synthesis,Spectra and DNA Intercalation of 2H-4,9-Dimethylfuro[2′,3′:5,6] naphtho [1,2-b] pyron-2-one

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