Chinese Journal of Applied Chemistry ›› 1995, Vol. 0 ›› Issue (1): 59-62.

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The Kelationship Between Activities and Conformations of Steroids

Xu Lu, Yao Yuyuan   

  1. Changchun Institute of Applied chemistry, Chinese Academy of Sciences, Changchun 130022
  • Received:1994-03-14 Revised:1994-06-15 Published:1995-02-10 Online:1995-02-10

Abstract: The molecular mechnics calculation has been performed for conformation analysisof steroids, The results reveal that there are two factors which importantly influence the ac-tivity of the steroids,namely the specific substitution sites(R1 and R2) and the steric posi-tion and energy of oxygen atoms in the compounds.

Key words: steroid, activity conformation, molecular mechanics