Synthesis of Liposomes of Oleoyl Mitomycin C and Its Antitumor Activity

Chinese Journal of Applied Chemistry ›› 1994, Vol. 0 ›› Issue (5): 98-100.

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Synthesis of Liposomes of Oleoyl Mitomycin C and Its Antitumor Activity

Wu Daocheng¹, Xu Liang², Zhang Xueyong²

1. Department of Chemistry, The Fourth Military Medical Universily, Xi'an710032;
2. Center of Gastroenterology, Xijing Hospital, The Fourth Military Medical University, Xi'an

Received:1994-01-03 Revised:1994-05-04 Published:1994-10-10 Online:1994-10-10

Abstract

Abstract: The oleoyl mitomycin C was synthesized by reacting mitomycin C with oleic acid.Its structure was determined by elementary analysis,¹H NMR spectra and IR spectra. The liposome of oleoyl mitomycin was prepared by a modified reverse-phase evaporation method.The antitumor assay on mice indicated that this liposome showed 2.2 times more powerful cytotoxicity to human gastric cancer cell line than MMC and very low cytotoxicity to normal human embryonic lung cell line.

Key words: oleoyl mitomycin C, liposome, antitumor activity

Wu Daocheng, Xu Liang, Zhang Xueyong. Synthesis of Liposomes of Oleoyl Mitomycin C and Its Antitumor Activity[J]. Chinese Journal of Applied Chemistry, 1994, 0(5): 98-100.

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Synthesis of Liposomes of Oleoyl Mitomycin C and Its Antitumor Activity

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