Chinese Journal of Applied Chemistry ›› 1993, Vol. 0 ›› Issue (3): 42-46.

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SYNTHESIS OF ADENINE DERIVATIVES BY SOLID-LIQUID PHASE TRANSFER CATALYSIS

Wang Zhicai, Lin Dianwei, Zheng Qihuang   

  1. Department of Chemistry, Zhongshan University, 510275 Guangzhou
  • Received:1992-07-14 Revised:1992-12-08 Published:1993-06-10 Online:1993-06-10

Abstract: Adenine derivatives as pharmaceuticals-eritadenine (1), ethyl 4-(6-amino-9H-purine-9-yl)-2(R), 3(R)-dihydroxybutyrate (1a),β-adenylpropionic acid (2) and ethyl β-adenylpropionate (2a) have been synthesized by solid-liquid phase transfer eatalysis. The effects of reaction conditions on the yields were studied. The results showed that PEG is a good phase transfer catalyst for the reaction.

Key words: adenine derivative, solid-liquid phase transfer catalysis, synthesis