Chinese Journal of Applied Chemistry ›› 1992, Vol. 0 ›› Issue (6): 57-60.

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SYNTHESIS,CHARACTERIZATION AND ANTITUMOR ACTIⅥTY OF TETRAPLATINUM(Ⅳ) ANALOGUE COMPLEXES

Shao Weiping1, Guan Yintong1, Tang Wenxia1, Ji Xiujuan2   

  1. 1. Institute of Coordination Chemistry, Nanjing University, Nanjing 210008;
    2. Institute of Materia Medica, Chinese Academy of Medical Science, Beijing
  • Received:1991-12-23 Revised:1992-05-18 Published:1992-12-10 Online:1992-12-10

Abstract: Five tetraplatinum (Ⅳ)analogue complexes were synthesized and characterized, The antitumour activity of the synthesized complexes against S-180 in mice and their water and ethylacetate solubilities were determined, The complex of was found to have a higher activity, The relationship between the activity of the complexes and their water and ethylacetate solubilities, the mechanism of the action of Pt (Ⅳ)complexes were discussed.

Key words: antitumor activity, tetraplatinum (Ⅳ) complex, S-180 sarcoma