Chinese Journal of Applied Chemistry ›› 1992, Vol. 0 ›› Issue (5): 44-49.

• Full Papers • Previous Articles     Next Articles

SYNTHESES AND NMR STUDIES OF POLYDENTATE PLATINUM COMPLEXES

Yang Zhiyong, Hu Jiehan, Liu Xiumei, Yang Zhenyun   

  1. Dalian Institute of Chemical Physics, Academia Sinica, Dalian 116012
  • Received:1991-06-28 Revised:1992-04-03 Published:1992-10-10 Online:1992-10-10

Abstract: Some platinum complexes PtA2X2 have been synthesed (A ammonia, isopropylamine; X2H2 aspartic, thiodiglycollic and N-alkyl substituted iminodiaeetic acid). The complexes were characterized by 1H NMR, 13C NMR and IR spectra. The results show that thiodiglycolic acid coordinates to Pt through S, O, O atoms, aspartic acid coordinates to Pt through N, O atoms. For N-alkyl substituted iminodiacetic acid two stable complexes were formed; at pH>5.5 this acid coordinates to Pt through N,O atoms and at pH<4 through N, O, O atoms.The stabilities of the complexes in aqueous solution were also investigated

Key words: platinum, complex, NMR, antitumor agent