SYNTHESIS, CHARACTERIZATION AND ANTITUMORIGENIC ACTIVITY OF CARBOPLATIN ANALOGUES

Chinese Journal of Applied Chemistry ›› 1989, Vol. 0 ›› Issue (3): 10-14.

• Full Papers • Previous Articles Next Articles

SYNTHESIS, CHARACTERIZATION AND ANTITUMORIGENIC ACTIVITY OF CARBOPLATIN ANALOGUES

Feng Juncai¹, Huang Zheyuan¹, Ni Yaping¹, Dong Yanhong¹, Tang Wenxia¹, Ji Xiujuan², Liu Xiaomei², Wang Longgui²

1. Coordination Chemistry Institute, Nanjing University;
2. Institute of Materia Medica, Chinese Academy of Medical Science, Beijing

Received:1988-09-12 Revised:1988-11-24 Published:1989-06-10 Online:1989-06-10

Abstract

Abstract: Eighteen new complexes PtA₂X A = NH₃,CH₃NH₂, 1/2 en(ethylenediamine) and 1/2 dmbn 2,3- dimethy 1-2,3-butanediamine);X = CPrDCA (cyclopropane-1,1-dicarboxylic acid),2-M-CPrDCA (2-methyl-cyclopropane-1,1-dicarboxylic acid), 2-M-CBDCA (2-methyl-cyclobutane-1,1-dicarboxylic acid),CPDCA (cyclopentane-1,1-dicarboxylic acid) and CHDCA(cyclohexane-1,1-dicarboxylic acid))have been synthesized and characterized. It is found that the activities of complexes[Pt(NH₃)₂X] against W-256 in rats are in following order:CPrDCA > 2-M-CPrDCA > CPDCA > CBDCA(carboplatin) 2-M-CBDCA.

Key words: Platinum complex, Carboplatin, Antitumor, Cycloalkane dicarboxylic acid

Feng Juncai, Huang Zheyuan, Ni Yaping, Dong Yanhong, Tang Wenxia, Ji Xiujuan, Liu Xiaomei, Wang Longgui. SYNTHESIS, CHARACTERIZATION AND ANTITUMORIGENIC ACTIVITY OF CARBOPLATIN ANALOGUES[J]. Chinese Journal of Applied Chemistry, 1989, 0(3): 10-14.

[1]	ZHANG Hui-Li, CUI Hong-Yan, HUANG Wen-Long, HU Guo-Qiang. Synthesis and Antitumor Activity of Rhodanine Methylene-Substituted Levofloxacin Derivatives [J]. Chinese Journal of Applied Chemistry, 2021, 38(2): 188-194.
[2]	WU Xue-Jiao, GOU Guang-Lin, YANG Xiao-Lan, YANG Jia-Qiang. Synthesis and Antitumor Activity of Phosphonate Derivatives Containing Dipeptide [J]. Chinese Journal of Applied Chemistry, 2021, 38(1): 36-43.
[3]	ZHANG Sijia, XU Caina, CHEN Jie, TIAN Huayu, CHEN Xuesi. Enhancing T Cell Antitumor Activity by Regulating Tumor Metabolism [J]. Chinese Journal of Applied Chemistry, 2020, 37(9): 977-984.
[4]	ZHANG Huili, CUI Hongyan, HUANG Wenlong, HU Guoqiang. Synthesis and Antitumor Activity of 3-Arylidene-Quinolin-4-Ones Derivatives of Levofloxacin [J]. Chinese Journal of Applied Chemistry, 2020, 37(12): 1426-1431.
[5]	QIU Na, SHI Xiao, YANG Yiyi, SONG Nannan, LI Jiajia, GE Zhenying, ZHANG Lei. Synthesis and Anti-colorectal Cancer Activity of Amphipathic Trimethine Indocyanine Dyes [J]. Chinese Journal of Applied Chemistry, 2020, 37(11): 0-0.
[6]	QIU Na, SHI Xiao, YANG Yiyi, SONG Nannan, LI Jiajia, GE Zhenying, ZHANG Lei. Synthesis and Anti-colorectal Cancer Activity of Amphipathic Trimethine Indocyanine Dyes [J]. Chinese Journal of Applied Chemistry, 2020, 37(11): 1262-1267.
[7]	ZHANG Huili, LI Ke, HUANG Wenlong, WANG Rui, HU Guoqiang. Synthesis and Antitumor Activity of N-Arylidene-Rhodanine Levofloxacin Amides [J]. Chinese Journal of Applied Chemistry, 2019, 36(8): 897-903.
[8]	LI Yuanyuan,ZHANG Chengxia,HUANG Wenlong,CHEN Chaoran,HU Guoqiang. Synthesis and Antitumor Activities of C-3 Thiazolotriazole Unsaturated Ketone Derivatives of Levofloxacoin [J]. Chinese Journal of Applied Chemistry, 2019, 36(6): 671-676.
[9]	GUI Shuya,XIONG Hao,LIN Zhi,XIA Linya,ZHONG Qisheng,LI Dongfeng,HOU Ruibin,XIA Yan. Synthesis and Primary Antitumor Proliferation of p-Adamantanylcinnamides [J]. Chinese Journal of Applied Chemistry, 2018, 35(4): 420-425.
[10]	LIU Changhui,WEN Ruiming,HE Miao,YI Xianwen,YE Xiaoqin,FANG Lei. Synthesis and Antitumor Activities of Novel Thiosemicarbazone Derivatives with Ionone-Based Bischalcone [J]. Chinese Journal of Applied Chemistry, 2017, 34(8): 899-904.
[11]	KOU Lidong, WANG Wei. Synthesis and Antitumor Activity of Tetrahydroimidazo[2',1':2,3]thiazolo [5,4-c]piperdine Derivatives [J]. Chinese Journal of Applied Chemistry, 2017, 34(8): 905-911.
[12]	LI Na,LI Hui. Synthesis and Antitumor Activity of Hexahydro-1H-pyrrolo [3,4-d] Pyrimidine Derivatives [J]. Chinese Journal of Applied Chemistry, 2017, 34(5): 541-549.
[13]	MA Tao, YANG Jinhui, NIU Mingjie, YE Ziping, LI Fanghui. Total Synthesis and Antitumor Activity of Three 6-Geranylated Flavanones [J]. Chinese Journal of Applied Chemistry, 2017, 34(10): 1140-1149.
[14]	TAN Xuxia, LI Shining, ZHAO Jie, MAO Shen, MAO Longfei, XU Guiqing. Synthesis and Antitumor Activity of Novel 4H-1,2,4-Benzothiadiazine 1,1-Dioxide Derivatives [J]. Chinese Journal of Applied Chemistry, 2016, 33(9): 1067-1072.
[15]	CHEN Meijun, LI Jinhai, ZHANG Zhijia, LIAO Siyan, HUANG Yan, TAN Yin. Synthesis and Anti-tumor Evaluation of Nitrile-Containing Gambogic Acid Derivatives [J]. Chinese Journal of Applied Chemistry, 2016, 33(8): 905-912.

SYNTHESIS, CHARACTERIZATION AND ANTITUMORIGENIC ACTIVITY OF CARBOPLATIN ANALOGUES

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments