Preparation, Antibacterial Activity of Thiourea-chitosan-Co(II) Complex and Interaction with Bovine Serium Albumin

doi:10.3724/SP.J.1095.2011.00375

Chinese Journal of Applied Chemistry ›› 2011, Vol. 28 ›› Issue (09): 1012-1016.DOI: 10.3724/SP.J.1095.2011.00375

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Preparation, Antibacterial Activity of Thiourea-chitosan-Co(II) Complex and Interaction with Bovine Serium Albumin

FENG Xiaoqiang*, LI Xiaofang, YANG Sheng

(College of Life Science and Chemistry,Tianshui Normal University,Tianshui 741001)

Received:2010-06-28 Revised:2010-09-12 Published:2011-09-10 Online:2011-09-10

Abstract

Abstract:

Thiourea-chitosan-Co(Ⅱ) complex was prepared and characterized by FT-IR, UV-Vis absorbance spectra and TG-DTA methods, the antibacterial activities of thiourea-chitosan-Co(Ⅱ) complex against E.coli and St.aureus were studied in vitro. Moreover, the interaction between thiourea-chitosan-Co(Ⅱ) complex and bovine serum albumin(BSA) was also studied by ultraviolet and fluorescence spectroscopies. The results confirm that the complex is formed, and the antibacterial activities of thiourea-chitosan-Co(Ⅱ) complex is obviously enhanced comparing to its ligands and the complex can quench the intrinsic fluorescence of BSA.

Key words: Thiourea-Chitosan-Co(II) complex, Antibacterial activity, Bovine Serum Albumin

CLC Number:

O632.6

FENG Xiaoqiang*, LI Xiaofang, YANG Sheng. Preparation, Antibacterial Activity of Thiourea-chitosan-Co(II) Complex and Interaction with Bovine Serium Albumin[J]. Chinese Journal of Applied Chemistry, 2011, 28(09): 1012-1016.

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Preparation, Antibacterial Activity of Thiourea-chitosan-Co(II) Complex and Interaction with Bovine Serium Albumin

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